Microfluidic generation of barcodes with in situ synthesized perovskite quantum dot encapsulation  

作　　者：Feika Bian Lingyu Sun Yu Wang Dagan Zhang Zhiyang Li Yuanjin Zhao 

机构地区：[1]Department of Clinical Laboratory,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,210008,China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China

出　　处：《Science China Chemistry》2021年第9期1540-1546,共7页中国科学（化学英文版）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060,61971216);the Key Research and Development Project of Jiangsu Province(BE2019603,BE2019761,BE2020768);Jiangsu Province Top Health Talents Project(LGY2019001);Shenzhen Fundamental Research Program(JCYJ20190813152616459);the project funded by China Postdoctoral Science Foundation(2020M681556,2021T140318)。

摘　　要：Perovskite quantum dots(PQDs)are new class of optoelectronic materials,which have been widely studied for their extraordinary physical properties.Attempts to develop these materials are tending to make their fabrication much controllable and extend their values in different areas.Here,we present a novel strategy for one-step in situ synthesis of PQD-encapsulated barcode particles with the assistance of microfluidic technique.By changing the halide ratio in perovskite precursor solutions that emulsified in microfluidic devices,a series of PQDs with different colors have been successfully fabricated,which made them ideal materials as barcodes.Because of the stable encapsulation of ethyleneglycol dimethacrylate(EGDMA)resin,the PQD-encapsulated barcode particles were with no cytotoxicity and could be anti-quenched.It was demonstrated for the first time that the PQD-encapsutated barcode particles by microfluidics were valuable for multiplex biomolecular encoding and assays.These features indicate that the PQD-encapsutated barcode particles by microfluidics are ideal for many practical applications and have a broad prospect in biomedical field.

关 键 词：microfluidics droplet perovskite quantum dot BARCODE JANUS 

分 类 号：TB34[一般工业技术—材料科学与工程] TN204[电子电信—物理电子学]