Visible light induced tandem reactions:An efficient one pot strategy for constructing quinazolinones using in-situ formed aldehydes under photocatalyst-free and room-temperature conditions  

作　　者：Zongbo Xie Jin Lan Haibo Zhu Gaoyi Lei Guofang Jiang Zhanggao Le 

机构地区：[1]Jiangxi Province Key Laboratory of Synthetic Chemistry,School of Chemistry,Biology and Material Science,East China University of Technology,Nanchang 330013,China

出　　处：《Chinese Chemical Letters》2021年第4期1427-1431,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.21462001);a Science and Technology Project of Jiangxi Province (No.20192BBH80012)。

摘　　要：A facile tandem route has been developed for constructing quinazolinones from various aminobenzamides and in-situ generated aldehydes.Visible light was found to play a dual role:first oxidizes the alcohol to the aldehyde and then facilitates its cyclization with o-substituted aniline.Furthermore,alcohols are perfe ct alternatives to aldehydes because they are greene r,more available,more economical,more stable,and less toxic tha n aldehydes.The first reaction step continuously provides material for the second step,which effectively reduces loss through volatilization,oxidation,and polymerization of the aldehyde,while avoiding its toxicity.A variety of quinazolinones can be prepared in the presence of visible light without any additional photocatalyst.The developed synthesis protocol proceeds with the merits of mild conditions,broad substrate scope,operational simplicity,a nd high atom efficiency,with an eco-energy source under metal-free,photocatalyst-free,and ambient conditions.

关 键 词：Visible light Photocatalyst-free In-situ formed acetaldehyde One pot tandem reaction QUINAZOLINONES Room temperature 

分 类 号：O626[理学—有机化学]