Aphamines A-C,dimeric acyclic diterpene enantiomers from Aphanamixis polystachya  

作　　者：Panpan Zhang Shang Xue Pengfei Tang Zhirong Cui Zefan Wang Jun Luo Lingyi Kong 

机构地区：[1]State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research.School of Traditional Chinese Pharmacy,ChinaPharnaceutical University,Nanjing 210009,China

出　　处：《Chinese Chemical Letters》2021年第4期1480-1484,共5页中国化学快报（英文版）

基　　金：Financial support for this study is from the National Natural Science Foundation of China (No.31470416);the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT_15R63);the "Double First-Class" University Project,China (No.CPU2018GY08);the 111 Project from Ministry of Education ofChina and the State Administration of Foreign Export Affairs of China (No.B18056);the National New Drug Innovation Major Project (No.2018ZX09711-001-007)。

摘　　要：Aphamines A-C(1-3),three pairs of acyclic diterpene dimer enantiomers with an unprecedent ploymerization pattern,were discovered from Aphanamixis polystachya by NMR-guided isolation and chiral resolution.The elucidation of their novel carbon skeletons was achieved based on spectroscopic analysis,exciton chirality,and calculated electronic circular dichroism(ECD).Plausible Claisen rearrangement,5-exo-trig cyclization,and reduction reactions may play important roles in the polymeric biosynthesis pathway.Compounds 1 and 3 showed inhibitory effects on nitric oxide(NO)production(IC_(50):6.71-15.36 μmol/L) and reduced the expression of iNOS in LPS-induced RAW 264.7 macrophages.

关 键 词：Aphanamixis polystachya Acyclic diterpene dimer NMR-guided isolation Chiral resolution Anti-inflammatory activity 

分 类 号：TQ317[化学工程—高聚物工业]