低氧诱导因子1α基因多态性与重症感染急性肾损伤的关系  

Analysis of relationship between hypoxia-inducible factor 1αgene polymorphism and acute kidney injury in patients with severe infection

作　　者：黄志杰[1] 赵永华[2] 田立民 孟伟[4] 刘秀明[5] HUANG Zhi-jie;ZHAO Yong-hua;TIAN Li-min;MENG Wei;LIU Xiu-ming(Langfang Peoples Hospital,Langfang,Hebei 065000,China;不详)

机构地区：[1]廊坊市人民医院感染科,河北廊坊065000 [2]廊坊市人民医院ICU,河北廊坊065000 [3]廊坊广安医院ICU,河北廊坊065000 [4]廊坊市人民医院放射科,河北廊坊065000 [5]廊坊市人民医院感控科,河北廊坊065000

出　　处：《中华医院感染学杂志》2021年第16期2426-2430,共5页Chinese Journal of Nosocomiology

基　　金：河北省卫健委科研基金资助项目(20201303)。

摘　　要：目的分析身体质量指数(BMI)及低氧诱导因子1α(HIF-1α)基因多态性与重症感染患者急性肾损伤(AKI)的关系。方法选择2017年1月-2019年6月廊坊市人民医院诊治的122例重症感染患者,根据是否并发AKI将患者分为AKI组(n=53)和非AKI组(n=69),比较两组患者BMI,检测HIF-1α基因单核苷酸多态性(SNP)位点多态性,并分析BMI以及HIF-1α基因多态性与重症感染患者并发AKI的关系。结果AKI组BMI高于非AKI组(P<0.05);AKI组HIF-1α基因rs11549465位点CC基因型分布频率和C等位基因频率低于非AKI组(P<0.05),CT+TT基因型分布频率和T等位基因频率高于非AKI组(P<0.05);AKI组HIF-1α基因rs11549467位点GG基因型分布频率和G等位基因频率低于非AKI组(P<0.05),GA+AA基因型分布频率和A等位基因频率高于非AKI组(P<0.05);在超显性、显性模型下,AKI组HIF-1α基因rs11549465、rs11549467位点各基因型分布频率与非AKI组比较,差异有统计学意义(P<0.05),分别与CC、GG基因型比较,CT+TT、GA+AA基因型重症感染患者并发AKI风险增加;多因素Logistic回归分析显示,BMI、HIF-1α基因rs11549465位点CT+TT基因型、rs11549467位点GA+AA基因型是影响重症感染患者AKI发生的危险因素。结论BMI指数以及HIF-1α基因rs11549465位点CT+TT基因型和rs11549467位点GA+AA基因型可能会增加重症感染患者并发AKI的风险。OBJECTIVE To analyze the relationship between body mass index(BMI)and hypoxia-inducible factor 1α(HIF-1α)gene polymorphisms and acute kidney injury(AKI)in patients with severe infection.METHODS A total of 122 patients with severe infection diagnosed and treated in the People’s Hospital of Langfang from Jan 2017 to Jun 2019 were recruited.The patients were divided into the AKI group(n=53)and non-AKI group(n=69)according to whether they were complicated with AKI.The BMI index was compared between the two groups,and the locus polymorphism of single nucleotide polymorphism(SNP)of HIF-1αgene was detected.The relationship between BMI index and HIF-1αgene polymorphism and AKI in patients with severe infection was analyzed.RESULTS The BMI index in the AKI group was significantly higher than that in the non-AKI group(P<0.05).The CC genotype distribution frequency and C allele frequency at rs11549465 locus of HIF-1αgene in the AKI group were significantly lower than those in the non-AKI group(P<0.05)while the CT+TT genotype distribution frequency and T allele frequency were significantly higher than those in the non-AKI group(P<0.05).The GG genotype distribution frequency and G allele frequency at rs11549467 locus of HIF-1αgene in the AKI group were significantly lower than those in the non-AKI group(P<0.05)while the GA+AA genotype distribution frequency and A allele frequency were significantly higher than those in the non-AKI group(P<0.05).Under the superdominant or dominant model,there were significant differences in the distribution frequencies of genotypes at rs11549465 locus and rs11549467 locus of HIF-1αgene between the AKI group and non-AKI group(P<0.05).Compared with CC and GG genotypes,patients with severe infection carrying CT+TT and GA+AA genotypes had higher risk of AKI.Multivariate Logistic regression analysis showed that BMI index,CT+TT genotype at rs11549465 locus and GA+AA genotype at rs11549467 locus of HIF-1αgene were risk factors affecting the occurrence of AKI in patients with severe infectio

关 键 词：身体质量指数 低氧诱导因子1Α 基因多态性 重症感染 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学]