基于我省药品不良反应报告探讨输液反应影响因素及临床表现  

Investigation on Influencing Factors and Clinical Manifestations of Transfusion Reaction Based on the Adverse Drug Reaction Reports in Our Province

作　　者：赵云洁 司继刚[2] 段磊[2] 吴世福[3] ZHAO Yunjie;SI Jigang;DUAN Lei;WU Shifu(Binzhou Medical University,Binzhou,Shandong,China 264003;Zibo Central Hospital,Zibo,Shandong,China 255036;Shandong Provincial Center for ADR Monitoring,Jinan,Shandong,China 250014)

机构地区：[1]滨州医学院,山东滨州264003 [2]山东省淄博市中心医院,山东淄博255036 [3]山东省药品不良反应监测中心,山东济南250014

出　　处：《中国药业》2021年第18期114-116,共3页China Pharmaceuticals

基　　金：2019年度山东省药品不良反应监测哨点立项课题[鲁药监测〔2019〕119号]。

摘　　要：目的促进临床安全、合理用药。方法统计2019年山东省上报国家药品不良反应监测中心的药品不良反应报告数据,筛选其中含有寒战、发热、高热、体温升高、输液反应等的病例,分析人群结构、发生时间、药物因素等,探讨影响输液反应的各种因素,并分析淄博市临淄区人民医院上报病例具体用药情况及不良反应临床表现。结果筛选到输液反应病例3882例,其中,淄博市临淄区人民医院上报16例。输液反应的发生与患者性别无关,年龄以61~80岁发生率最高(46.34%),药物分布以抗感染药物发生率最高(26.12%),季节以秋季(9月至11月)发生率最高(31.09%)。具体表现形式为体温升高、寒战、喘憋、皮肤发红发热、恶心呕吐等,严重的有低血压休克、呼吸衰竭等。结论临床工作应加强安全用药管理,从药品的储存、处方、配置、使用方法、人员素质等多个方面把关,避免或减少输液反应的发生,保障临床用药安全、有效。Objective To promote clinical safety and rational drug use.Methods The adverse drug reaction(ADR)data of Shandong Province reported to the National Center for ADR Monitoring in 2019 were collected,and the ADR cases with shiver,fever,high fever,elevated body temperature and infusion reaction were screened.The population structure,occurrence time and drug factors were analyzed to investigate the various factors affecting infusion reaction.The specific drug use and clinical manifestations of ADR cases reported by the Linzi District People’s Hospital of Zibo City were analyzed.Results A total of 3882 cases of infusion reaction were screened,of which 16 cases were reported by the Linzi District People’s Hospital of Zibo City.The incidence of infusion reaction was not related to the patient’s gender.In terms of age,the incidence of infusion reaction was the highest in patients aged 61-80 years(46.34%).In terms of drugs,the incidence of infusion reaction of anti-infective drugs was the highest(26.12%).In terms of season,the incidence of infusion reaction was the highest in autumn(from September to November,31.09%).The clinical manifestations of infusion reaction included body temperature rise,shivering,wheezing and suffocating,skin redness and fever,nausea and vomiting,etc,and serious reactions were hypotension shock,respiratory failure,etc.Conclusion In order to avoid or reduce the occurrence of transfusion reaction and ensure the safety and effectiveness of clinical drug use,we should strengthen the management of safe drug use in clinical work,and check the storage,prescription,configuration,usage and personnel quality of drugs.

关 键 词：输液反应 影响因素 临床表现 药事管理 药品不良反应 用药安全 

分 类 号：R95[医药卫生—药学]