富血小板浓缩物在鼓膜穿孔中的疗效及研究进展  

The Effectiveness and Research Progress of Platelet-Rich Concentrate Products in Tympanic Membrane Perforation

作　　者：黄钧涛 袁喆晨 胡时雨 吕翠婷 胡益 沈毅 HUANG Juntao;YUAN Zhechen;HU Shiyu;LU Cuiting;HU Yi;SHEN Yiu(Department of Otolaryngology Head and Neck Surgery,Affiliated Lihuili Hospital of Ningbo University(Ningbo Medical Center of Lihuili Hospital),Ningbo 315040,China;School of Medicine,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学附属李惠利医院(宁波市医疗中心李惠利医院)耳鼻咽喉头颈外科,宁波315040 [2]宁波大学医学院,宁波315211

出　　处：《中国细胞生物学学报》2021年第8期1700-1704,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81670920);浙江省医药卫生科技计划项目(批准号:2020RC107、2020KY274);浙江省自然科学基金(批准号:LY15H130003);宁波市自然科学基金(批准号:2018A610363);宁波市惠民技术研发项目(批准号:2015C50026)资助的课题。

摘　　要：鼓膜穿孔(tympanic membrane perforation,TMP)是耳鼻咽喉科常见的疾病。急性TMP多数能自愈,而慢性TMP现主要使用手术治疗,然而现有手术治疗方法均存在缺陷,例如需要全麻、费用较高、技巧复杂等,故探究更佳的治疗方法显得尤为重要。富血小板浓缩物主要包括富血小板血浆(platelet-rich plasma,PRP)和富血小板纤维(platelet-rich fibrin,PRF),其富含生长因子和白细胞,故可有效促进组织再生,并降低感染发生率。以往作为新型修复材料,PRP和PRF已被应用于耳科治疗TMP,并被证实在TMP愈合中具有良好的疗效。因此,该文将对近年来血小板浓缩物用于TMP修复的文献进行回顾与总结分析。TMP(tympanic membrane perforation)represents a common problem in otorhinolaryngology.Acute TMP can heal spontaneously but the chronic TMP require surgical interventions.Due to the limitation of conventional surgery including the requirements of general anesthesia,high costs and complicated surgical technologies,it is important to explore alternatives to solve these limitations.Platelet-rich concentrate products,including PRP(platelet-rich plasma)and PRF(platelet-rich fibrin).It is full of growth factors and white blood cell,which can effectively promote tissue regeneration and reduce the incidence of infection.As new materials in ontology,PRP and PRF have been applied in TM repair during the decades.This study will review and summarize the effectiveness of platelet concentrate products in the treatment of TM perforation according to previous studies.

关 键 词：富血小板血浆 富血小板纤维 鼓膜穿孔 愈合 

分 类 号：R764[医药卫生—耳鼻咽喉科]