趋化因子CCL3在病理性疼痛和阿片耐受中的作用  

Roles of Chemokine CCL3 in Pathologic Pain and Opioid Tolerance

作　　者：李凤娇 史永慧 王冬梅[1] LI Fengjiao;SHI Yonghui;WANG Dongmei(Fujian Key Laboratory of Developmental and Neurobiology,College of Life Science,Fujian Normal University,Fuzhou 350108,China)

机构地区：[1]福建师范大学生命科学学院,福建省发育与神经生物学重点实验室,福州350108

出　　处：《中国细胞生物学学报》2021年第8期1722-1728,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81400922、81571084);福建省自然科学基金(批准号:2020J05038);福建师范大学经费(批准号:Y2020jg07)资助的课题。

摘　　要：趋化因子配体3[chemokine(C-C motif)ligand 3,CCL3]是趋化因子家族的一员,广泛表达于神经系统和免疫系统中。研究表明,CCL3可通过募集免疫细胞、激活细胞内的信号通路以及介导神经元与神经胶质细胞间的相互作用,从而参与神经病理性疼痛、炎性痛的发生及维持。此外,CCL3还可引起μ型阿片肽受体(mu opioid receptor,MOR)脱敏,从而影响吗啡等的镇痛作用,并参与阿片耐受的形成过程。该文综述了CCL3及其受体在病理性疼痛和阿片耐受中的作用。CCL3[chemokine(C-C motif)ligand 3]is a member of the chemokine family and is widely expressed in the nervous and immune systems.Studies have shown that CCL3 plays a role in the occurrence and maintenance of neuropathic and inflammatory pain by recruiting immune cells,activating intracellular signaling pathways and mediating the interaction between neurons and glial cells.In addition,CCL3 can also cause MOR(μopioid receptor)desensitization,thus affecting the analgesic effects of morphine and participating in the formation of opioid tolerance.This paper reviews the roles of CCL3 and its receptor in pathological pain and opioid tolerance.

关 键 词：病理性疼痛 趋化因子 CCL3 阿片耐受 

分 类 号：R402[医药卫生—临床医学]