黄芪注射液辅助治疗脓毒症患者的效果及对其免疫细胞、细胞因子水平的影响  

Effect of Astragalus Injection in Adjuvant Treatment of Sepsis Patients and Its Effect onLevelsof Immune Cells and Cytokines

作　　者：阮俊[1] 王利粉[1] 徐慕娟[1] RUAN Jun;WANG Lifan;XU Mujuan(Shenzhen Hospital of Traditional Chinese Medicine,Shenzhen 518033,Guangdong,China)

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《实用中医内科杂志》2021年第8期66-68,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：广东省中医药局科研项目(20172120)。

摘　　要：目的探讨黄芪注射液辅助治疗脓毒症患者的效果及对其免疫细胞、细胞因子水平的影响。方法选取深圳市中医院收治的2018年12月—2020年12月60例脓毒症患者研究对象,按照简单随机化法将上述患者分为对照组和观察组,其中对照组30例采用常规治疗,治疗组30例则在对照组的基础上采用黄芪注射液辅助治疗,对比分析两组患者治疗后的临床效果、治疗前后的免疫细胞指标及血清炎性因子指标水平。结果观察组患者的临床总有效率为90.00%(27/30),高于对照组患者的临床总有效率60.00%(18/30),差异具有统计学意义(P<0.05);与治疗前相比,治疗后两组患者的CD_(4)^(+)水平均升高,且观察组高于对照组,而CD_(8)^(+)水平均降低,且观察组低于对照组,而观察组CD_(4)^(+)/CD_(8)^(+)显著升高,对照组CD_(4)^(+)/CD_(8)^(+)明显降低,差异具有统计学意义(P<0.05);与治疗前相比,治疗后观察组患者的血清肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α),白介素细胞-6(Interleukin-6,IL-6),白介素细胞-1β(Interleukin-1β,IL-1β)水平均降低,而对照组血清IL-6、TNF-α、IL-1β水平均升高,但观察组低于对照组,差异具有统计学意义(P<0.05)。结论黄芪注射液辅助治疗可显著提高脓毒症患者的治疗效果,改善患者的免疫功能,同时还可以有效的降低血清炎性因子水平,值得在临床上研究进一步的推广与应用。Objective To investigate the effect of Astragalus Injection in the adjuvant treatment of patients with sepsis and its effect on the levels of immune cells and cytokines. Methods Sixty patients with sepsis in our hospital from December 2018 to December 2020 were divided into groups according to simple randomization method. The control group(n=30) received conventional treatment, and the treatment group(n=30) received adjuvant treatment with Astragalus Injection on the basis of the control group. The clinical effects, immune cells and serum inflammatory factors of the two groups were compared. Results The total effective rate of observation group was 90.00%, which was higher than that of control group(P<0.05). Compared with those before treatment, the CD_(4)^(+) levels in two groups were increasedafter treatment, and the observation group’s level was higher than that of the control group, while the CD_(8)^(+) level was decreased, and the observation group’s level was lower than that of the control group.The observation group’s CD_(4)^(+)/CD_(8)^(+)was increased, and that of the control group was decreased(P<0.05). Compared with those before treatment, serum levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and interleukin-1β(IL-1β) in the observation group were decreased after treatment. The serum levels of IL-6, TNF-α and IL-1β in the control group were increased, and those in the observation group were lower than those in the control group(P<0.05). Conclusion The adjuvant therapy of Astragalus Injection can improve the therapeutic effect of sepsis patients and the immune function, and reduce the levels of serum inflammatory factors.

关 键 词：脓毒症 黄芪注射液 免疫细胞 细胞因子 

分 类 号：R278[医药卫生—中医学]