中药痛风清解汤联合止痛消炎软膏与金黄散外敷治疗急性期痛风性关节炎的效果分析  

Effect of Tongfeng Qingjie Decoction(痛风清解汤)Combined with Internal Medicine and Pain-Relieving and Anti-Inflammatory Ointment Plus External Application of Jinhuang Powder on Acute Stage Gouty Arthritis

作　　者：曾继勇[1] 廖婧 江斌[1] 梁桂芳 ZENG Jiyong;LIAO Jing;JIANG Bin;LIANG Guifang(Traditional Chinese Medicine Hospital in Panyu District,Guangzhou 511400,Guangdong,China)

机构地区：[1]广州市番禺区中医院,广东广州511400

出　　处：《实用中医内科杂志》2021年第8期138-140,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：广州市番禺区科技计划(2017-Z04-51)。

摘　　要：目的探讨分析痛风清解汤、止痛消炎软膏联合金黄散治疗急性期痛风性关节炎(AGA)临床效果。方法选择医院2018年2月—2019年11月诊治的100例AGA患者,按乱数表法分为中西组51例和西药组49例,西药组接受常规西药治疗,中西组在西药治疗基础上内服痛风清解汤,外敷止痛消炎软膏和金黄散,观察两组的关节症状缓解、生化指标、炎症指标。结果两组治疗前的中医中医症状积分对比差异无统计学意义(P>0.05),中西组治疗后的关节压痛、肿胀的中医症状积分为别为(1.58±0.31)分、(1.75±0.31)分,低于西药组的(2.85±0.36)分、(2.40±0.35)分(P<0.05);两组治疗前的尿酸(UA)、环氧合酶-2(COX-2)对比差异无统计学意义(P>0.05),中西组治疗后的UA、COX-2水平分别为(291.54±13.78)μmol/L、(12.26±2.14)ng/L,低于西药组(380.12±15.24)μmol/L、(15.74±2.21)ng/L(P<0.05);两组治疗前的肿瘤坏死因子α(TNF-α)、前列腺素E2(PGE2)、C反应蛋白(CRP)对比差异无统计学意义(P>0.05),中西组治疗后的TNF-α、PGE2、CRP分别为(12.47±2.06)pg/mL、(14.57±2.03)pg/mL、(5.28±0.77)mg/L,均低于西药组的(13.68±2.19)pg/mL、(18.20±2.11)pg/mL、(6.59±0.82)mg/L(P<0.05)。结论痛风汤剂和外敷药膏治疗可通过降低AGA患者炎症水平,有效缓解其关节疼痛、肿胀症状。Objective To analyze the clinical effects of Tongfeng Qingjie Decoction(痛风清解汤) and Pain-Relieving Anti-Inflammatory Ointment combined with Jinhuang Powderin the treatment of gouty arthritis(AGA) in the acute phase.Methods A total of 100 patients with AGA diagnosed in our hospital from February 2018 to November 2019 were selected and divided into a combination of Chinese and Western medicine group(n=51) and a western medicine group(n= 49) according to a scrambled number table, while the western medicine group received conventional Western drug treatment, and the combination of Chinese and Western medicine group received Tongfeng Qingjie Decoction orally, Pain-Relieving Anti-Inflammatory Ointmentand Jinhuang Powder externally on the basis of Western medicine treatment. The joint symptoms relief, biochemical indexesand inflammatory indexes of the two groups were observed.Results The TCM symptom scores before treatment were not significantly different between the two groups(P>0.05), and the TCM symptom scores of joint tenderness and swelling after treatment in the combination of Chinese and western medicine group were(1.58±0.31) points and(1.75±0.31) points, which were lower than those in the western medicine group[(2.85±0.36) points,(2.40±0.35) points](P<0.05), and levels of uric acid(UA) and cyclooxygenase-2(COX-2) before treatment in the two groups werewas not significantly different(P>0.05). The levels of UA and COX-2 in the combination of Chinese and western medicine group after treatment were(291.54±13.78)μmol/L and(12.26±2.14)ng/L, which were lower than those in the western medicine group[(380.12±15.24)μmol/L,(15.74±2.21)ng/L ](P<0.05). The levels of tumor necrosis factor alpha(TNF-α), prostaglandin E2(PGE2) and C-reactive protein(CRP) before treatment in the two groups were not significantly different(P>0.05). The levels ofTNF-α, PGE2, and CRP in the combination of Chinese and western medicine group after treatment were(12.47±2.06)pg/mL,(14.57±2.03)pg/mL and(5.28±0.77)mg/L, respective

关 键 词：痛风清解汤 止痛消炎软膏 急性期痛风性关节炎 金黄散 

分 类 号：R259[医药卫生—中西医结合]