中国有生育力男性精子浓度35年变化趋势分析  

Trend of change in sperm concentration in Chinese fertile males from 1984 to 2019

作　　者：李昕[1] 李豫 邵骏[3] 邵永 黄智龙 LI Xin;LI Yu;SHAO Jun;SHAO Yong;HUANG Zhi-long(School of Statistics,East China Normal University,Shanghai 200241,China;Department of Andrology,Southern Medical University/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Reproductive Medicine,Nantong Maternity and Child Health Hospital,Nantongy Jiangsu 226018,China;Department of Reproductive Medicine,Nanjing School of Clinical Medicine,Southern Medical University/General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Urology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250021,China)

机构地区：[1]华东师范大学统计学院,上海200241 [2]南方医科大学南京临床医学院/东部战区总医院男科,江苏南京210002 [3]江苏省南通市妇幼保健院生殖医学中心,江苏南通226018 [4]南方医科大学南京临床医学院/东部战区总医院生殖医学科,江苏南京210002 [5]山东第一医科大学附属省立医院泌尿外科,山东济南250021

出　　处：《中华男科学杂志》2021年第7期645-648,共4页National Journal of Andrology

摘　　要：目的:研究1984~2019年间中国有生育力男性精子浓度的变化趋势。方法:检索中国知网、维普、万方数据库收录的历年发表的精子浓度相关文献,系统收集相关数据及信息,分析近35年来中国有生育力男性精子浓度的变化。结果:经拟合计算,1984~2019年间,中国优生生育力男性精子浓度总体呈下降趋势,精子浓度从98.848 6×10^(6)/ml降至72.553 1×10^(6)/ml,每年下降0.751 3×10^(6)/ml。根据地域分布分析,中国北方省份精子浓度下降幅度高于中国南方省份。结论:近35年来,中国有生育力男性精子浓度呈下降趋势,可能与不良生活习惯及环境污染日益加重相关,应加强相关基础领域研究。Objective: To investigate the trend of change in the sperm concentration of Chinese fertile males from 1984 to 2019. Methods: We searched CNKI, CQVIP and Wanfang Database for literature relevant to human sperm concentration published from 1984 to 2019, and analyzed the trend of change in the sperm concentration of fertile men in China in the past 35 years. Results: A total of 9 495 publications were identified, of which 73 with 11 606 subjects were included. Based on the results of fitting calculation, the perm concentration of the males declined significantly from 98.8486 ×10^(6)/ml in 1984 to 72.5531 ×10^(6)/ml in 2019, with a mean decrease of 0.7513 ×10^(6)/ml annually(P < 0.01), and the reduction was more significant in North than in South China(-1.2754 vs-0.4587 ×10^(6)/ml, P = 0.01). Conclusion: The sperm concentration of fertile Chinese men was decreasing in the past 35 years, which might be related to unhealthy living habits and environmental pollution.

关 键 词：精子浓度 精液质量 回归分析 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]