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作 者:侯丽娟[1] 臧莉[1] 王宏伟[1] 段树鹏[1] 宋新文[1] HOU Lijuan;ZANG Li;WANG Hongwei;DUAN Shupeng;SONG Xinwen(First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,Henan,China)
机构地区:[1]新乡医学院第一附属医院,河南新乡453100
出 处:《中华中医药学刊》2021年第8期183-185,共3页Chinese Archives of Traditional Chinese Medicine
基 金:中华医学会临床医学科研专项基金(16520685658);河南省教育厅重点项目(2007330001)。
摘 要:目的分析清热化湿活血法辅助治疗肝胆湿热型慢性乙型肝炎对患者白细胞介素-22(IL-22)和热休克蛋白70(HSP70)的影响。方法选取医院(2016年11月—2019年1月)收治的肝胆湿热型慢性乙型肝炎患者90例,分为两组。对照组给予常规护肝治疗,观察组给予清热化湿活血法辅助治疗,分析两组患者治疗后的临床效果。结果观察组中医证候总有效率(91.11%,41/45)高于对照组(75.56%,34/45),差异具有统计学意义(P<0.05)。两组治疗前乙肝病毒DNA(HBV-DNA)、肝功能指标、白细胞介素-12(IL-12)、IL-22、HSP70水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后HBV-DNA(2.48±0.91)lgcopies/mL、丙氨酸氨基转移酶(ALT)(74.65±14.96)U/L、天门冬氨酸氨基转移酶(AST)(62.89±12.11)U/L、总胆红素(TBIL)(32.02±10.74)μmol/L、IL-22(58.98±10.85)ng/L、HSP70(2.85±1.31)μg/L水平低于对照组,IL-12(32.11±6.22)pg/mL水平高于对照组(P<0.05)。结论清热化湿活血法辅助治疗肝胆湿热型慢性乙型肝炎可保护肝脏,调节IL-12、IL-22、HSP70的表达水平,提高治疗效果。Objective To analyze the effect of clearing away heat, removing dampness and activating blood circulation on IL-22(IL-22) and heat shock protein 70(HSP70) in patients with chronic hepatitis B of dampness-heat in liver and gallbladder type. Methods From November 2016 to January 2019, 90 patients with chronic hepatitis B with dampness and heat in liver and gallbladder type were divided into two groups. The control group was treated with routine liver protection treatment, and the observation group was treated with the method of clearing away heat and removing dampness and activating blood circulation. The clinical effect of the two groups after treatment was analyzed. Results The total effective rate of TCM syndrome in the observation group(91.11%,41/45) was higher than that in the control group(75.56%,34/45). The difference was statistically significant(P<0.05). There was no significant difference in the levels of hepatitis B virus(HBV-DNA), liver function, IL-12,IL-22 and HSP70 between the two groups before treatment. After treatment, the levels of HBV-DNA[(2.48±0.91)lgcopies/mL], alanine aminotransferase(ALT)[(74.65±14.96)U/L], aspartate aminotransferase(AST)[(62.89±12.11)U/L], total bilirubin(TBIL)[(32.02±10.74)μmol/L],IL-22[(58.98±10.85)ng/L] and HSP70[(2.85±1.31)μg/L] were lower than those in the control group and IL-12(32.11±6.22) pg/mL were lower than those in the control group. The level of IL-12 was higher than that of the control group(P<0.05). Conclusion The method of clearing away heat, removing dampness and activating blood circulation can protect the liver, regulate the expression levels of IL-12,IL-22 and HSP70 and improve the therapeutic effect.
关 键 词:清热化湿活血法 肝胆湿热型 慢性乙型肝炎 热休克蛋白70
分 类 号:R259.126.2[医药卫生—中西医结合]
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