不同类型肠内营养对感染性休克患者瘦素、血清趋化素等指标及预后的影响  

Effects of different types of enteral nutrition on leptin,serum chemokine and other indicators and prognosis in patients with septic shock

作　　者：陈欢 周伟[2] 许锁[2] 朱小浩[2] 李守林[2] 骆继业[2] CHEN Huan;ZHOU Wei;XU Suo;ZHU Xiaohao;LI Shoulin;LUO Jiye(Department of Emergency Medicine;Department of Emergency ICU,Lianyungang First People′s Hospital,Lianyungang,Jiangsu 222002,China)

机构地区：[1]连云港市第一人民医院急诊内科,江苏连云港222002 [2]连云港市第一人民医院急诊ICU,江苏连云港222002

出　　处：《国际检验医学杂志》2021年第18期2237-2240,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨不同类型肠内营养对感染性休克患者瘦素、血清趋化素等指标及预后的影响。方法选取连云港市第一人民医院收治的78例感染性休克患者,根据肠内营养治疗方式的不同分为研究组和对照组,其中研究组39例患者均采用免疫增强型肠内营养治疗,对照组39例患者均采用常规肠内营养混悬液治疗。比较两组患者治疗前后的炎性指标、脂肪因子指标、肠功能屏障指标及免疫指标水平,对比其治疗相关临床指标差异。结果研究组患者治疗后炎性指标、脂肪因子指标、肠功能屏障指标、免疫指标及相关临床指标水平均优于对照组治疗后,差异有统计学意义(P<0.05)。结论免疫增强型肠内营养治疗感染性休克患者的疗效较为显著,不仅可显著提高患者的免疫功能和肠功能屏障功能,同时还可减轻其炎性反应程度,并能很好地改善其预后,值得临床推广应用。Objective To investigate the effects of different types of enteral nutrition on leptin,serum chemokine and other indicators and prognosis in patients with septic shock.Methods 78 patients with septic shock in the Lianyungang First People′s Hospital were selected and divided into study group and control group according to different enteral nutrition treatment methods.39 patients in the study group were treated with immune enhanced enteral nutrition,and 39 patients in the control group were treated with conventional enteral nutrition suspension.The levels of inflammatory index,adipokines index,intestinal function barrier index and immunological index were compared between the two groups before and after treatment,and the differences of treatment-related clinical indexes were compared.Results The levels of inflammatory index,fat factor index,intestinal function barrier index,immunology index and related clinical indexes of the study group were better than those of the control group after treatment,with statistical significance(P<0.05).Conclusion The effect of immune enhanced enteral nutrition in the treatment of septic shock patients is more significant,not only can significantly improve the immune function and intestinal function barrier function of patients,but also can reduce the degree of inflammatory reaction,and can improve the prognosis,which is worthy of clinical application.

关 键 词：免疫增强型肠内营养 感染性休克 脂肪因子 炎性因子 预后 

分 类 号：R459.3[医药卫生—治疗学]