4-甲氧基-2,3,5-三甲基吡啶氮氧化物的合成  

Synthesis of 4-methoxy-2,3,5-trimethylpyridine Nitrogen Oxides

作　　者：李莹 唐春燕 许方亮 李立威[1] Li Ying;Tang Chunyan;Xu Fangliang;Li Liwei(College of Chemical Engineering and Pharmacy Jingchu University of Technology,Jingmen 448000,China)

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《广东化工》2021年第15期59-59,53,共2页Guangdong Chemical Industry

基　　金：国家级大学生创新训练项目(201811336008)。

摘　　要：以2,3,5-三甲基吡啶为起始原料,经氮氧化、溴代、甲氧基取代合成4-甲氧基-2,3,5-三甲基-吡啶氮氧化物,该合成工艺简单,原料便宜易得,反应条件温和,且避免了硝化反应等危险工艺,易于实施工业化生产。目标化合物结构经HNMR、MS确证。Using 2,3,5-trimethyl-pyridine as starting material, 4-methoxy-2,3,5-trimethyl-pyridine nitrogen oxide was synthesized by nitrogen oxidation,bromination and methoxy substitution. The synthesis process is simple, the raw material is cheap and easy to obtain, the reaction conditions are mild, and the nitrification reaction and other dangerous processes are avoided, and it is easy to carry out industrial production. The structures of the target compounds were confirmed by HNMR and MS.

关 键 词：氮氧化 溴代 甲氧基取代 合成 工艺改进 

分 类 号：TQ[化学工程]