Exfoliated FePS nanosheets for T-weighted magnetic resonance imaging-guided near-infrared photothermal therapy in vivo  

剥离的FePS3纳米片及其活体内T1加权磁共振成像介导的近红外光热治疗研究

作　　者：Ying Zhang Hongfang Du Panpan He Chuang Shen Qi Li Yefan Duan Zhouwei Shao Fei Mu Feng Huang Peiyang Li Pingqi Gao Peng Yu Zhimin Luo Lianhui Wang 张颖;都洪芳;何盼盼;沈闯;李琦;段叶凡;邵周伟;牟菲;黄峰;李霈旸;高平齐;于鹏;罗志敏;汪联辉(State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials(IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),College of Electronic and Optical Engineering&College of Microelectronic,Nanjing University of Posts and Telecommunications,Nanjing 210023,China;School of Materials Science and Engineering,State Key Laboratory of Optoelectronic Materials and Technologies,School of Materials,Sun Yat-sen University,Guangzhou 510275,China;Department of Human Anatomy,School of Basic Medical Sciences,Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province,Fujian Medical University,Fuzhou 350122,China)

机构地区：[1]State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials(IAM),Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM),College of Electronic and Optical Engineering&College of Microelectronic,Nanjing University of Posts and Telecommunications,Nanjing 210023,China [2]School of Materials Science and Engineering,State Key Laboratory of Optoelectronic Materials and Technologies,School of Materials,Sun Yat-sen University,Guangzhou 510275,China [3]Department of Human Anatomy,School of Basic Medical Sciences,Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province,Fujian Medical University,Fuzhou 350122,China

出　　处：《Science China Materials》2021年第10期2613-2623,共11页中国科学（材料科学（英文版）

基　　金：supported by the National Key Research and Development Program of China(2017YFA0205302);the Key Grant for Special Professors in Jiangsu Province(RK030STP18001);the Key Research and Development Program of Jiangsu(BE2018732);the Natural Science Key Fund for Colleges and Universities in Jiangsu Province(17KJA430011);the National Postdoctoral Program for Innovative Talents(BX20190156);the Scientific Research Foundation of Nanjing University of Posts and Telecommunications(NY218150);the Training Program of the Major Research Plan of the National Natural Science Foundation of China from Nanjing University of Posts and Telecommunications(NY218158);“1311 Talents Program”of Nanjing University of Posts and Telecommunications;“100 Top Talents Program”of Sun Yat-sen University(29000-18841216);“Young-Teacher Training Program”of Sun Yat-sen University(29000-31610036);Joint Funds for the Innovation of Science and Technology in Fujian Province(2017Y9111);the Natural Science Foundation of Fujian Province(2020J01613)。

摘　　要：Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine.Herein,thin-layered FePS3 nanosheets modified with amine polyethylene glycol(FePS3-PEG)are synthesized by ultrasonicated exfoliation of bulk Fe PS3 single crystals under Ar atmosphere and in situ chemical functionalization with amine PEG.The prepared Fe PS3-PEG nanosheets give a photothermal conversion efficiency of 22.1%under 808-nm laser and evident T1relaxation(r1=2.69(mmol L^(-1))^(-1)S^(-1))in external magnetic fields.Biologically experimental results in vitro and in vivo demonstrate that Fe PS3-PEG nanosheets have good biocompatibility and exhibit excellent photothermal therapy(PTT)effect under clear T1-weighted magnetic resonance imaging(MRI).The characteristics of Fe PS3-PEGnanosheets enable them to be a promising nanomedicine for T1-weighted MRI-guided near-infrared PTT of cancers.开发具有先进生物成像和高性能诊疗功能的纳米平台对于纳米科学与生物医药研究有重要意义.本文中,我们通过在氩气中超声剥离FePS3单晶并同步化学修饰氨基聚乙二醇制备了氨基聚乙二醇功能化的FePS3纳米片(FePS3-PEG),FePS3-PEG纳米片在808 nm激光下的光热转化效率可达22.1%,并在外界磁场中显示了明显的T1弛豫效应(r1=2.69(mmol L^(-1))^(-1)S^(-1)).体内外的生物实验结果表明,FePS3-PEG纳米片具有良好的生物相容性,在清晰的T1加权磁成像介导下展现出优异的光热治疗效果.FePS3-PEG纳米片的特性使其成为有前景的癌症T1加权磁成像介导的近红外光热治疗纳米药物.

关 键 词：photothermal therapy near infrared T1 magnetic resonance imaging thin-layered Fe PS3nanosheets bifunctional nanomedicine 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]