右美托咪啶与咪达唑仑治疗老年腹部手术后重症患者的效果  

Observation of the effect of dexmedetomidine and midazolam in senile patients after abdominal surgery

作　　者：刘喆吉 LIU Zheji(Department of Critical Medicine,the Second Affiliated Hospital of Shenyang Medical College,Shenyang,Liaoning,100002,China)

机构地区：[1]沈阳医学院附属第二医院重症医学科,辽宁沈阳100002

出　　处：《当代医学》2021年第27期39-41,共3页Contemporary Medicine

摘　　要：目的观察右美托咪啶与咪达唑仑治疗老年腹部手术后重症患者的效果。方法选取2017年1月至2019年1月本院收治的40例老年腹部手术后重症患者为研究对象,依据不同用药方案分为对照组(咪达唑仑)和实验组(右美托咪啶),各20例。比较两组患者镇静治疗效果。结果实验组手术时间明显短于对照组,手术失血量、尿量和输液量明显少于对照组(P<0.05)。术后1、3和7 d,实验组MMSE评分明显高于对照组(P<0.05)。术后,实验组TNF-α、IL-6、IL-1β、HMGBI均明显低于对照组,差异有统计学意义(P<0.05)。结论右美托咪啶治疗老年腹部手术后重症患者,具有良好的镇静作用,能改善患者的认知能力,临床应用价值较高。Objective To observe the effect of dexmedetomidine and midazolam in the treatment of elderly patients with severe abdominal surgery.Methods 40 elderly patients with severe post-abdominal surgery who were treated in our hospital from January 2017 to January 2019 were selected as study subjects.They were divided into control group(midazolam)and the experimental group(dexmedetomidine)according to different medication regimens,with 20 cases in each group.The sedation effect was compared between the two groups.Results The operation time in the experimental group was significantly shorter than the control group,and the blood loss,urine volume,and infusion volume were also significantly less than those in the control group(P<0.05).The MMSE scores in the experimental group were significantly higher than those in the control group after operation 1 d,3 d,and 7 d(P<0.05).After operation,TNF-α,IL-6,IL-1β,HMGBI in experimental group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine is used in elderly patients with severe postoperative abdominal surgery.It can play a good role in sedation and improve cognitive ability of patients,with high clinical application value.

关 键 词：右美托咪啶 咪达唑仑 老年腹部手术 重症 镇静效果 

分 类 号：R614[医药卫生—麻醉学]