猪氨基肽酶N作为受体介导猪冠状病毒感染的研究进展  

Review of Aminopeptidase N as the Receptor of Porcine Coronavirus Infection

作　　者：韦欣欣 李泽辉 靳晓慧[1,2] 魏战勇[1] WEI Xinxin;LI Zehui;JIN Xiaohui;WEI Zhanyong(College of Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China;Key Laboratory for Animal‑Derived Food Safety of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南农业大学动物医学院,河南郑州450046 [2]河南省动物性食品安全重点实验室,河南郑州450046

出　　处：《河南农业科学》2021年第8期1-8,共8页Journal of Henan Agricultural Sciences

基　　金：国家自然科学基金项目(31772773);国家自然科学基金联合基金项目(U1704231)。

摘　　要：猪氨基肽酶N(Porcine aminopeptidase N,pAPN)广泛地存在于猪组织细胞的膜表面,是一类对锌离子依赖性较强的膜结合Ⅱ型的金属跨膜糖蛋白。猪氨基肽酶作为一种功能性受体与猪冠状病毒的相互作用是目前猪冠状病毒研究热点之一。pAPN作为多种冠状病毒的受体,主要是通过识别和黏附冠状病毒S蛋白的受体结合域(Receptor binding domain,RBD)从而介导感染。综述了pAPN受体与不同猪冠状病毒结合机制方面的研究进展,分析不同猪冠状病毒在侵染宿主时与受体结合方式的异同,并对pAPN受体抑制剂的相关研究进行探讨,为研究猪冠状病毒感染机制提供参考,也为针对pAPN蛋白开发阻断冠状病毒感染的药物奠定基础。Porcine aminopeptidase N(pAPN)is a typeⅡzinic‑dependent membrane‑bound transmembrane glycoprotein,which is widely found on the surface of porcine tissue cells.Porcine aminopeptidase is a functional receptor,and its interaction with porcine coronavirus has become one of the hot‑spots of coronavirus research.As receptors of some coronaviruses,pAPN mediates coronavirus infection through recognizing and binding the receptor binding domain(RBD)of coronavirus S protein.In this review,we summarized the interaction mechanism of APN with viral proteins of different porcine coronavirus,analyzed the similarities and differences of their interactions,and discussed the influence of pAPN inhibitors on coronavirus infection.This review can offer a useful reference for studying the mechanism of porcine coronavirus infection,and provide a foundation for exploiting drugs which can block coronavirus infection.

关 键 词：冠状病毒 氨基肽酶N 猪冠状病毒 受体 受体抑制剂 

分 类 号：S855.3[农业科学—临床兽医学]