MCS+LDP和UPP程序单采血小板效果对比分析  

Comparative analysis of effects of MCS+LDP and UPP procedures on platelet apheresis

作　　者：陈岑[1] 齐瑛[1] 程文晋 褚晓凌[1] CHEN Cen;QI Ying;CHENG Wenjin;CHU Xiaoling(Second Department of Blood Donation Services,Fujian Blood Center,Fuzhou,Fujian 350004,China)

机构地区：[1]福建省血液中心献血服务二科,福建福州350004

出　　处：《检验医学与临床》2021年第18期2663-2666,2669,共5页Laboratory Medicine and Clinic

摘　　要：目的对便携式血液成分分离机(MCS+)由少白细胞血小板采集程序(LDP)升级至通用血小板采集程序(UPP)前后的数据进行分析比较,探讨程序升级的总体效果。方法血小板采集数据比较采用自身对照的方式,选择MCS+程序升级前后1年内分别采用LDP和UPP捐献血小板的献血者为研究对象,以不同性别、不同采集量(1个和2个治疗量)分组,按照同一献血者分别采用2种程序捐献同样治疗量的采集过程进行数据配对分析,共计216人次(男110人次,女106人次)。比较程序升级前后MCS+采集血小板的参数、质控结果及献血不良反应发生情况。结果无论采集1个治疗量还是2个治疗量,2种程序相同性别比较,血细胞比容(HCT)、采前血小板计数、采后血小板计数、全血处理量差异均无统计学意义(P>0.05);而UPP血小板采集时间短于LDP,血小板收集效率高于LDP,柠檬酸盐抗凝剂(ACD-A)用量多于LDP,差异均有统计学意义(P<0.05)。相同程序和采集量,不同性别比较,HCT差异有统计学意义(P<0.05),血小板采集时间、采前血小板计数、采后血小板计数、全血处理量、ACD-A用量、血小板收集效率差异均无统计学意义(P>0.05)。2种程序血小板质控抽检情况、献血不良反应(迷走神经反应和枸橼酸盐反应)比较,差异均无统计学意义(P>0.05)。结论UPP与LDP比较,采集时间缩短,血小板收集效率提高,献血不良反应发生率和产品质控抽检情况无差异,值得推广使用。但要根据各地献血人群条件,设置合适的采集基础参数,以采集高品质产品,提升献血者采集过程舒适度。Objective To analyze and compare the data before and after the upgrade of the portable blood component separator MCS+from the leukocyte-reduced platelet collection program(LDP)to the universal platelet collection program(UPP),and investigate the overall effect of the program upgrade.Methods Platelet collection data were compared by self-control.Blood donors who donated platelets with LDP and UPP within one year before and after the upgrading of MCS+program were selected as the research object.They were grouped by gender and different collection volume(1 and 2 treatment volumes).The data were paired and analyzed according to the collection process of the same blood donor donating the same treatment volume with 2 programs,a total of 216 person times(110 men and 106 women).The parameters,quality control results and adverse reactions of MCS+platelet collection before and after program upgrading were compared.Results Regardless of whether one treatment dose or two treatment doses were collected,there was no statistically significant difference in hematocrit(HCT),platelet count before collection,platelet count after collection,and whole blood processing volume between the two procedures for the same gender(P>0.05).The platelet collection time of UPP was shorter than that of LDP,the platelet collection efficiency was higher than that of LDP,and the amount of citrate anticoagulant(ACD-A)was more than that of LDP,the difference was statistically significant(P<0.05).The same procedure and collection volume,compared with different genders,HCT difference was statistically significant(P<0.05),platelet collection time,platelet count before collection,platelet count after collection,whole blood processing volume,ACD-A dosage,platelet collection efficiency the differences were not statistically significant(P>0.05).There were no statistically significant differences in the platelet quality control sampling and adverse blood donation reactions(vagus nerve reaction and citrate reaction)between the two procedures(P>0.05).Conclusion

关 键 词：单采血小板 机采血小板 血液成分分离机MCS+ 采集时间 

分 类 号：R457.1[医药卫生—治疗学]