尿TRF、NAG1和血清CysC对早期糖尿病肾病的诊断价值  

Diagnostic value of urinary TRF,NAG1 and serum CysC in patients with early diabetic nephropathy

作　　者：刘芳[1] 李扬宇[1] 毛起官 林青[1] LIU Fang;LI Yangyu;MAO Qiguan;LIN Qing(Department of Clinical Laboratory,Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350004,China)

机构地区：[1]福建中医药大学附属人民医院检验科,福建福州350004

出　　处：《检验医学与临床》2021年第18期2700-2702,2707,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨尿转铁蛋白(TRF)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG1)和血清胱抑素C(CysC)单项及联合检测对早期糖尿病肾病(DN)的诊断价值。方法选取2020年9-11月该院收治的2型糖尿病患者90例,根据尿微量清蛋白/肌酐比值(ACR)水平分为无并发症的单纯糖尿病组(DM组)、早期DN组、DN组,每组30例,另选取同期该院体检健康者30例作为对照组。检测所有受试者尿TRF、NAG1及血清CysC水平并进行统计学分析,采用受试者工作特征(ROC)曲线评价各指标的诊断价值。结果DN组尿TRF、NAG1及血清CysC水平高于早期DN组、DM组和对照组,早期DN组高于DM组和对照组,差异均有统计学意义(P<0.05)。尿TRF与NAG1、尿TRF与血清CysC、尿NAG1与血清CysC之间均呈正相关(r=0.58、0.34、0.56,P<0.05)。尿TRF、NAG1及血清CysC 3项联合检测诊断早期DN的曲线下面积为0.991,高于各指标单独检测的0.913、0.852和0.880(P<0.05)。结论尿TRF、NAG1及血清CysC可作为评估早期DN的有效指标,3项联合检测有助于提高诊断效能。Objective To investigate the diagnostic value of urinary transferrin(TRF),N-acetyl-β-D-glucosaminidase(NAG1)and serum cysteine protease inhibitor C(CysC)single and combined detection for early diabetic nephropathy(DN).Methods Ninety patients with type 2 diabetes who were admitted to the hospital from September 2020 to November 2020 were selected and divided into uncomplicated simple diabetes mellitus group(DM group),early DN Group and DN group according to the level of urinary microalbumin/creatinine ratio(ACR),30 cases in each group,30 cases of healthy people in the hospital during the same period were selected as the control group.The levels of Urine TRF,NAG1 and serum CysC were detected and analyzed statistically.The receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of each indicator.Results The levels of urinary TRF,NAG1 and serum CysC in the DN group were higher than those in the early DN group,DM group and the control group,and the early DN group was higher than the DM group and the control group,the differences were statistically significant(P<0.05).There was a positive correlation between urine TRF and NAG1,urine TRF and serum CysC,and urine NAG1 and serum CysC(r=0.58,0.34,0.56,P<0.05).The area under the ROC curve of the combined detection of urinary TRF,NAG1 and serum CysC in the diagnosis of early DN was 0.991,which was higher than the 0.913,0.852 and 0.880 detected by each indicator separately(P<0.05).Conclusion Urinary TRF,NAG1 and serum CysC can be used as effective indicators to evaluate early DN,the combined detection of the three can help improve the diagnostic efficiency.

关 键 词：糖尿病肾病 尿转铁蛋白 N-乙酰-Β-D-氨基葡萄糖苷酶 胱抑素C 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]