脓毒性休克患者血清VEGFR-2、Ang-2、VE-Cad水平与病情严重程度及预后的相关性  

Correlation of serum VEGFR-2,ANG-2,VE-Cad levels with severity and prognosis in patients with septic shock

作　　者：关玉东 唐海峰 刘传明 王彦军 赵威 李俊杰 黄杨 尹文 GUAN Yudong;TANG Haifeng;LIU Chuanming;WANG Yanjun;ZHAO Wei;LI Junjie;HUANG Yang;YIN Wen(Department of Emergency,First Affiliated Hospital of PLA Air Force Military Medical University,Xi′an,Shaanxi 710032,China)

机构地区：[1]空军军医大学第一附属医院急诊科,陕西西安710032

出　　处：《检验医学与临床》2021年第18期2708-2711,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨脓毒性休克患者血清血管内皮生长因子受体2(VEGFR-2)、血管生成素-2(Ang-2)、血管内皮钙黏蛋白(VE-Cad)水平与病情严重程度及预后的相关性。方法选择2016年6月至2020年6月该院治疗的110例脓毒性休克患者作为休克组,另选择同期该院100例体检健康者作为对照组。休克组根据发病后28天预后情况分为存活组(64例),死亡组(46例)。比较休克组与对照组血清VEGFR-2、Ang-2、VE-Cad水平,存活组与死亡组的血清VEGFR-2、Ang-2、VE-Cad水平及急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分及脓毒症相关性器官功能衰竭评价(SOFA)评分;分析血清VEGFR-2、Ang-2、VE-Cad水平与APACHEⅡ、SOFA评分的相关性。结果休克组血清VEGFR-2、VE-Cad水平高于对照组,Ang-2水平低于对照组,差异均有统计学意义(P<0.05);存活组血清VEGFR-2、VE-Cad水平及APACHEⅡ、SOFA评分低于死亡组,Ang-2水平高于死亡组,差异均有统计学意义(P<0.05);血清VEGFR-2、VE-Cad和APACHEⅡ、SOFA评分均呈正相关(r=0.287、0.553、0.502、0.602,P<0.05),血清Ang-2和APACHEⅡ、SOFA评分均呈负相关(r=-0.334、-0.366,P<0.05)。结论血清VEGFR-2、Ang-2、VE-Cad参与了脓毒性休克的发生、发展过程,并与患者的病情严重程度和预后密切相关。Objective To investigate the relationship between serum vascular endothelial growth factor receptor 2(VEGFR-2),angiopoietin-2(Ang-2)and vascular endothelial cadherin(VE-Cad)levels in patients with septic shock and the severity and prognosis of the disease.Methods A total of 110 patients with septic shock treated in this hospital from June 2016 to June 2020 were selected as the shock group,and 100 healthy patients with physical examination in the same hospital during the same period were selected as the control group.According to the prognosis after 28 days,the shock group was divided into the survival group(64 cases)and the death group(46 cases).The levels of serum VEGFR-2,Ang-2 and VE-Cad in the shock group and the control group were compared,the levels of serum VEGFR-2,Ang-2 and VE-Cad,the score of acute physiology and chronic health status evaluationⅡ(APACHEⅡ)and the score of sepsis related organ failure(SOFA)in the survival group and the death group were compared.The correlation between the levels of serum VEGFR-2,Ang-2 and VE-Cad with APACHEⅡand sofa scores was analyzed.Results The levels of serum VEGFR-2 and VE-Cad in the shock group were higher than those in the control group,and the levels of Ang-2 were lower than those in the control group,the differences were statistically significant(P<0.05).The levels of serum VEGFR-2,VE-Cad,APACHEⅡand SOFA scores in the survival group were lower than those in the death group,and the Ang-2 levels were higher than those in the death group,the differences were statistically significant(P<0.05).There was a positive correlation between serum VEGFR-2,VE-Cad with APACHEⅡand SOFA scores(r=0.287,0.553,0.502,0.602,P<0.05),and there was a negative correlation between serum Ang-2 with APACHEⅡand SOFA scores(r=-0.334,-0.366,P<0.05).Conclusion Serum VEGFR-2,ANG-2 and VE-Cad are involved in the occurrence and development of septic shock,and are closely related to the severity and prognosis of disease.

关 键 词：脓毒性休克 血管内皮生长因子受体2 血管生存素2 血管内皮钙黏蛋白 

分 类 号：R459.7[医药卫生—急诊医学]