盐酸沙格雷酯联合阿司匹林在股浅动脉药物涂层球囊术后的临床疗效  

Clinical Efficacy of Sarpogrelate Combined with Aspirin in the Treatment of Superficial Femoral Artery Drug-Coated Balloon

作　　者：杨耀博 颜昭勇 肖亮 陈思攀[1] YANG Yaobo;YAN Zhaoyong;XIAO Liang(Department of Interventional Radiology,Shaanxi Provincial Peopled Hospital,Xian,Shaanxi Province 710068,P.R.China)

机构地区：[1]陕西省人民医院介入放射科,西安710068 [2]中国医科大学附属第四医院介入科,110000

出　　处：《临床放射学杂志》2021年第6期1197-1201,共5页Journal of Clinical Radiology

基　　金：国家自然科学基金项目(编号:81471763)。

摘　　要：目的研究盐酸沙格雷酯联合阿司匹林治疗股浅动脉药物球囊扩张术后的效果。方法搜集首次行股浅动脉药物球囊扩张术的患者,根据用药情况将患者分为观察组(36例)和对照组(36例)。观察组:盐酸沙格雷+阿司匹林;对照组:氯吡格雷+阿司匹林。术后即开始分组治疗,应用彩色多普勒超声、计算机断层扫描血管造影或数字减影血管造影进行定期随访检查。结果术后6个月观察组和对照组各病变部位的再狭窄率分别为8.3%和19.4%,术后12个月再狭窄率分别为22.2%和33.3%;最小管腔直径分别为(2.92±0.39)mm和(1.9±0.33)mm(P<0.001);晚期管腔损失分别为(0.42±0.18)mm和(1.34±0.19)mm(P<0.05);平均峰值流速比分别为2.19±0.72和2.67±0.84(P=0.01);观察组Rutherford分级3、4级明显少于对照组。结论盐酸沙格雷酯与氯吡格雷相比可以显著降低股浅动脉药物球囊扩张术后血管内膜增生及再狭窄的发生率。Objective To study the effect of sarpogrelate hydrochloride combined with aspirin in the treatment of superficial femoral artery balloon dilation.Methods The patients who underwent superficial femoral artery balloon dilatation with drugs for the first time in our hospital were collected,and the patients were divided into observation group(36 cases)and control group(36 cases)according to their medication status.Observation group:sarpogrelate hydrochloride+aspirin;control group:clopidogrel+aspirin.Group treatment started immediately after surgery,using color doppler ultrasound(DUS),computed tomography angiography(computed tomography angiography,CTA)or digital subtraction angiography for regular follow-up examinations(digital subtraction angiography,DSA).Results 6 months after operation,the restenosis rate of each lesion in the observation group and control group was 8.3%%and 19.4%,respectively.The restenosis rate at 12 months after operation was 22.2%and 33.3%,respectively;minimal lumen diameter(MLD:(2.92±0.39)mm vs(1.9±0.33)mm(P<0.001));late lumen loss(late lumen loss,LLL):(0.42±0.18)mm vs(1.34±0.19)mm(P<0.05);average peak velocity ratio(peak systolic velocity rati,PSVR):2.19±0.72 vs 2.67±0.84(P=0.01);The observation group’s Rutherford grades 3 and 4 were significantly lower than those of the control group.Conclusion Compared with clopidogrel,sarpogrelate hydrochloride can significantly reduce the incidence of intimal hyperplasia and restenosis after superficial femoral artery balloon dilation.

关 键 词：盐酸沙格雷酯 氯吡格雷 药物球囊 再狭窄 

分 类 号：R654.2[医药卫生—外科学]