脓毒症患者血清I-FABP、D-Lac、hs-CRP水平的变化及其临床意义  

Changes and clinical significance of serum I-FABP,D-Lac,and hs-CRP in patients with sepsis

作　　者：杨火保[1] 刘进生[2] 郑彩罚 YANG Huo-bao;LIU Jin-sheng;ZHENG Cai-fa(Department of Critical Care,Fujian Medical University Provincial School of Clinical Medicine/Fujian Provincial Hospital,Fuzhou 350001,Fujian,CHINA;Gastrointestinal Surgery,Fujian Medical University Provincial School of Clinical Medicine/Fujian Provincial Hospital,Fuzhou 350001,Fujian,CHINA)

机构地区：[1]福建医科大学省立临床医学院/福建省立医院重症医学科,福建福州350001 [2]福建医科大学省立临床医学院/福建省立医院胃肠外科,福建福州350001

出　　处：《海南医学》2021年第18期2331-2333,共3页Hainan Medical Journal

摘　　要：目的探讨脓毒症患者血清肠型脂肪酸结合蛋白(I-FABP)、D-乳酸(D-Lac)、高敏C反应蛋白(hs-CRP)水平的变化及其临床意义。方法回顾性分析2019年4月至2021年4月福建省立医院收治的83例脓毒症患者的临床资料,将合并脓毒症休克的45例患者纳入休克组,未合并脓毒症休克的38例患者纳入无休克组,另选择同期在我院行健康体检的50例健康者作为对照组。比较三组受检者的I-FABP、D-Lac和Hs-CRP水平。将脓毒症患者按照感染部位分为腹腔感染组(n=57)和非腹腔感染组(n=26),比较两组患者的血清I-FABP、D-Lac、hs-CRP水平。结果脓毒症无休克组与休克组患者的I-FABP、D-Lac、hs-CRP水平分别为(28.64±5.36)ng/mL、(15.83±7.36)mg/L、(52.41±9.47)mg/L与(37.94±5.91)ng/mL、(28.41±8.86)mg/L、(66.53±14.39)mg/L,明显高于对照组的(18.15±2.39)ng/mL、(9.26±3.18)mg/L、(8.36±2.11)mg/L,且无休克组患者的I-FABP、D-Lac、hs-CRP水平明显低于休克组,差异均有统计学意义(P<0.05);腹腔感染组患者的血清I-FABP、hs-CRP水平分别为(35.93±5.92)ng/mL、(65.14±15.27)mg/L,明显高于非腹腔感染组的(24.72±7.25)ng/mL、(49.72±8.26)mg/L,差异均有统计学意义(P<0.05);但腹腔感染组患者的血清D-Lac水平为(25.43±11.62)mg/L,与非腹腔感染组的(30.67±13.81)mg/L比较差异无统计学意义(P>0.05)。结论脓毒症患者血清I-FABP、D-Lac、hs-CRP水平均明显升高,且合并脓毒症休克的患者升高更加明显,可以作为反应脓毒症疾病严重程度的重要指标,而血清I-FABP、hs-CRP水平在脓毒症腹腔感染患者中明显升高。Objective To explore the changes and clinical significance of serum intestinal fatty acid bind-ing protein(I-FABP),D-lactic acid(D-Lac),and high-sensitivity C-reactive protein(hs-CRP)in patients with sep-sis.Methods The clinical data of 83 patients with sepsis treated in Fujian Provincial Hospital from April 2019 to April 2021 were retrospectively analyzed.Forty-five patients with septic shock were included into the shock group,and 38 patients without septic shock were included into the non-shock group.Fifty healthy people who received the physical examination in the hospital served as the control group.The levels of I-FABP,D-Lac,and hs-CRP in the three groups of subjects were compared.The sepsis patients were divided into 57 cases of abdominal infection group and 26 cases of non-abdominal infection group according to the site of infection.The serum I-FABP,D-Lac,and hs-CRP levels of the two groups were compared.Results The levels of I-FABP,D-Lac,and hs-CRP in the non-shock group and shock group were(28.64±5.36)ng/mL,(15.83±7.36)mg/L,(52.41±9.47)mg/L and(37.94±5.91)ng/mL,(28.41±8.86)mg/L,(66.53±14.39)mg/L,respectively,which were significantly higher than corresponding(18.15±2.39)ng/mL,(9.26±3.18)mg/L,(8.36±2.11)mg/L of the control group;the levels of I-FABP,D-Lac,and hs-CRP in the sepsis group were significantly lower than those in the shock group(all P<0.05);serum I-FABP and hs-CRP levels in the abdominal infec-tion group were(35.93±5.92)ng/mL and(65.14±15.27)mg/L,which were significantly higher than corresponding(24.72±7.25)ng/mL,(49.72±8.26)mg/L of the non-abdominal infection group(P<0.05);the serum D-Lac level of the abdominal infection group was(25.43±11.62)mg/L versus(30.67±13.81)mg/L of the non-abdominal infection group(P>0.05).Conclusion The levels of serum I-FABP,D-lac,and hs-CRP in patients with sepsis are significantly in-creased,especially in patients with septic shock,which can be used as an important indicator of the severity of sepsis.The levels of serum I-FABP and hs-CRP in patients

关 键 词：脓毒症 脓毒性休克 肠型脂肪酸结合蛋白 D-乳酸 高敏C反应蛋白 肠道损伤 

分 类 号：R631[医药卫生—外科学]