冠心病患者血清IMA、cathepsin S、RBP4水平与炎性因子及心肌缺血程度的相关性研究  

The Study of Correlation between Serum IMA,Cathepsin S,RBP4 Levels and Inflammatory Factors and Degree of Myocardial Ischemia in Patients with Coronary Heart Disease

作　　者：陈入菲 郑俊晨[2] 秦建宁 杨濛 王芸 CHEN Ru-fei;ZHENG Jun-chein;QIN Jian-ning;YANG Meng;WANG Yun(Department of Internal Medicine-Cardiovascular,Xi'an Third Hospital Affiliated to Northwest University,Xi'an,Shaanxi,71001&China;Department of Cardio vascular Medical Center,Dongguan Branch of Yan'an University Affiliated Hospital,Yan'an,Shaanxi,716000,China)

机构地区：[1]西北大学附属西安市第三医院心血管内科,陕西西安710018 [2]延安大学附属医院东关分院心脏血管医学中心,陕西延安716000

出　　处：《现代生物医学进展》2021年第16期3101-3105,共5页Progress in Modern Biomedicine

基　　金：陕西省教育厅专项科研计划项目(16JK1667)。

摘　　要：目的:探讨血清缺血修饰白蛋白(IMA)、组织蛋白酶S(cathepsin S)、视黄醇结合蛋白4(RBP4)水平与冠心病患者炎性因子、心肌缺血程度的相关性。方法:选择2017年2月至2019年10月我院收治的100例冠心病患者,根据心肌缺血程度分为稳定型心绞痛组(34例)、不稳定型心绞痛组(42例)、急性心肌梗死组(24例)。检测并比较患者血清IMA、cathepsin S、RBP4、炎性因子[白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]水平,分析IMA、cathepsin S、RBP4与炎性因子、SYNTAX积分的相关性,采用多元有序Logistic回归分析影响冠心病患者心肌缺血程度的因素。结果:冠心病患者心肌缺血程度越严重,血清IMA、cathepsin S、RBP4及炎性因子水平越高(P<0.05)。Pearson相关性分析结果显示,血清IMA、cathepsin S、RBP4水平与炎性因子、SYNTAX积分均呈正相关(P<0.05)。多元有序Logistic回归分析结果显示,高CRP、IMA、cathepsin S、RBP4水平是冠心病心肌缺血程度的影响因素(OR=1.702、1.183、1.881、2.003,P<0.05)。结论:血清IMA、cathepsin S、RBP4水平与冠心病患者心肌缺血程度及炎性因子有关,IMA、cathepsin S、RBP4可能与炎症反应共同作用参与冠心病发病过程。Objective:To investigate the correlation between serum ischemia modified albumin(IMA),cathepsin S,retinol binding protein 4(RBP4)levels and inflammatory factors and degree of myocardial ischemia in patients with coronary heart disease.Methods:100 patients with coronary heart disease who were admitted to the department of cardiology of our hospital from February 2017 to October 2019 were selected,according to the degree of myocardial ischemia,they were divided into stable angina group(34 cases),unstable angina group(42 cases)and acute myocardial infarction group(24 cases).The levels of serum IMA,cathepsin S,RBP4,inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),and TNF-α]in the patients were measured and compared,the correlation between IMA,cathepsin S,RBP4,inflammatory factors,SYNTAX scores were analyzed.The factors influencing the degree of myocardial ischemia in patients with coronary heart disease were analyzed by multiple ordered logistic regression.Results:The more serious myocardial ischemia of the patients with coronary heart disease was,the higher levels of serum IMA,cathepsin S,RBP4 and inflammatory factors were(P<0.05).Pearson correlation analysis results showed that levels of serum IMA,cathepsin S and RBP4 were positively correlated with inflammatory factors and SYNTAX scores(P<0.05).The results of multiple ordered Logistic regression analysis showed that high levels of CRP,IMA,cathepsin S and RBP4 were the influencing factors of the degree of myocardial ischemia of coronary heart disease(OR=1.702,1.813,1.881,2.003,P<0.05).Conclusion:The levels of serum IMA,cathepsin S and RBP4 are correlated with myocardial ischemia and inflammatory factors in patients with coronary heart disease,IMA,cathepsin S and RBP4 may participate in the pathogenesis of coronary heart disease together with inflammatory response.

关 键 词：冠心病 缺血修饰白蛋白 组织蛋白酶S 视黄醇结合蛋白4 炎性因子 SYNTAX积分 

分 类 号：R541.4[医药卫生—心血管疾病]