急性心力衰竭患者血清miRNA-21、MYO、CK-MB与心功能和预后的关系  

Analysis of the Relationship between Serum miRNA-21,MYO,CK-MB and Cardiac Function and Prognosis in Patients with Acute Heart Failure

作　　者：闫玉敏[1] 肖四海[1] 常绍菊[1] 刘婷婷[1] 王希柱[1] 宋巧凤[1] 张志敏[2] YAN Yu-min;XIAO Si-hai;CHANG Shao-ju;LIU Ting-ting;WANG Xi-zhu;SONG Qiao-feng;ZHANG Zhi-min(Department of Cardiovascular Medicine,Tangshan People's Hospital,Tangshan,Hebei,063000,China;The Affiliated Hospital of Chengde Medical College,Chengde,Hebei,067000,China)

机构地区：[1]唐山市人民医院心血管内科,河北唐山063000 [2]承德医学院附属医院,河北承德067000

出　　处：《现代生物医学进展》2021年第16期3170-3174,共5页Progress in Modern Biomedicine

基　　金：河北省医学科学研究计划项目(20160868)。

摘　　要：目的:探讨急性心力衰竭患者血清mi RNA-21、肌红蛋白(MYO)、心肌肌酸激酶同工酶(CK-MB)与心功能和预后的关系。方法:选择2018年2月至2019年2月于我院接诊的95例急性心力衰竭患者为研究对象(病例组),另选择同期在我院进行检查的80例健康人为对照组,分析两组患者血清mi RNA-21、MYO、CK-MB、左心室射血分数(LVEF)、左心房内径(LAD)、左心室舒张末期内径(LVEd)水平变化情况及和预后相关性。结果:病例组患者血清mi RNA-21、MYO、CK-MB水平显著高于对照组,差异显著(P<0.05);病例组患者LAD、LVEd水平显著高于对照组,LVEF水平显著低于对照组,差异显著(P<0.05);II级患者血清mi RNA-21、MYO、CK-MB水平显著低于Ⅲ级、IV级患者,Ⅲ级患者血清mi RNA-21、MYO、CK-MB水平显著低于IV级患者,差异显著(P<0.05);预后良好组患者血清mi RNA-21、MYO、CK-MB水平显著低于预后不良组,差异显著(P<0.05);Spearman相关分析显示,血清mi RNA-21、MYO及CK-MB和LVEF之间均呈负相关,血清mi RNA-21、MYO及CK-MB和LAD、LVEd之间均呈正相关,(P<0.05);Logistic回归分析结果显示,血清mi RNA-21、MYO及CK-MB及LVEF、LAD、LVEd为急性心力衰竭患者预后的影响因素(P<0.05)。结论:急性心力衰竭患者血清mi RNA-21、MYO、CK-MB的表达升高,其与心功能和预后密切相关。Objective:To study Analysis of the Relationship between serum mi RNA-21,Myoglobin(MYO),myocardial creatine kinase isoenzyme(CK-MB)and cardiac function and prognosis in patients with acute heart failure.Methods:95 patients with acute heart failure admitted to our hospital from February 2018 to February 2019 were selected as the research subjects(case group).In addition,80 healthy patients who underwent examination in our hospital during the same period were selected as the control group,and the changes of serum mi RNA-21,MYO,CK-MB,left ventricular ejection fraction(LVEF),left atrial diameter(LAD),and left ventricular end-diastolic diameter(LVED)levels and their correlation with prognosis were analyzed in 2 groups.Results:The levels of serum mi RNA-21,MYO and CK-MB in case group were significantly higher than those in control group,and the differences were significant(P<0.05).LAD and LVED levels in case group were significantly higher than those in control group,and LVEF levels were significantly lower than those in control group(P<0.05).The serum mi RNA-21,MYO,CK-MB levels in grade II patients were significantly lower than those in gradeⅢand IV patients,and the serum mi RNA-21,MYO,CK-MB levels in gradeⅢpatients were significantly lower than those in grade IV patients,the difference was significant(P<0.05).The levels of serum mi RNA-21,MYO and CK-MB in the good prognosis group were significantly lower than those in the poor prognosis group,with significant differences(P<0.05).Spearman correlation analysis showed that serum mi RNA-21,MYO,CK-MB and LVEF were negatively correlated,while serum mi RNA-21,MYO,CK-MB and LAD and LVEF were positively correlated(P<0.05).Logistic regression analysis showed that serum mi RNA-21,MYO,CK-MB,LVEF,LAD,LVED were the prognostic factors in patients with acute heart failure(P<0.05).Conclusion:The expression of mi RNA-21,MYO and CK-MB in patients with acute heart failure is increased,which is closely related to cardiac function and prognosis.

关 键 词：急性心力衰竭 mi RNA-21 肌红蛋白 心肌肌酸激酶同工酶 心功能 预后 

分 类 号：R541.61[医药卫生—心血管疾病]