交泰固精汤治疗早泄心肾不交证的临床研究  

Clinical study on the efficacy of Jiaotai Gujing decoction on premature ejaculation with syndrome of Xin-Shen incoordination

作　　者：孙迪 赵凡 张春和 王澍弘 李美材 余清霞 Sun Di;Zhao Fan;Zhang Chunhe;Wang Shuhong;Li Meicai;Yu Qingxia(Department of Andrology,Chongqing University Three Gorges Hospital/Chongqing Three Gorges Central Hospital,Chongqing 404000;Department of Urology and A ndrology,Affilialed Hospital of Nantong University,Nantong 226001;Department qf Andrology,Yunnan Provincial Hospital of Traditional Chinese Medicine/The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China;Yunnan Universityof Chinese Medicine,Kunming 650500,China)

机构地区：[1]重庆大学附属三峡医院/重庆三峡中心医院男科,重庆404000 [2]南通大学附属医院泌尿外科/男科,江苏南通226001 [3]云南省中医医院/云南中医药大学第一附属医院男科,云南昆明650021 [4]云南中医药大学,云南昆明650500

出　　处：《中国男科学杂志》2021年第4期25-28,共4页Chinese Journal of Andrology

基　　金：国家自然科学基金项目(30760316);云南省卫生科技计划项目(2016NS18);重庆市卫生计生委中医药科技项目指导项目(ZY20173066)。

摘　　要：目的初探交泰固精汤治疗早泄心肾不交证的临床疗效。方法本研究采用自身前后对照临床试验方法。纳入的35例早泄患者均服用交泰固精汤免煎配方颗粒(2次/日,200ml/次)。采集患者治疗前、治疗4周及8周后的相关观察指标,包括阴道内射精潜伏期(IELT)、中医证候积分和临床总体印象变化(CGIC)。结果与治疗前相比,治疗4周后IELT、中医证候积分及CGIC均显著改善(P均<0.01);治疗8周后IELT、中医证候积分及CGIC亦均显著改善(P均<0.01),且明显优于治疗4周(P均<0.01)。治疗4周和8周后的IELT改善总有效率分别为45.71%(16/35)和88.57%(31/35),两者间差异具有显著统计学意义(P<0.01)。35例患者在本临床试验中均未出现明显不良反应。结论初步证实口服交泰固精汤对早泄心肾不交证的疗效较佳,但仍需进一步研究。Objective T o explore the clinical efficacy of JiaotaiGujing decoction on premature ejaculation(PE)with syndrome of Xin-Shen incoordination preliminarily.Methods This study was a self-controlled clinical trial.All the patients with PE were treated with Jiaotai Gujing decoction(prescription granules,twice a day,once 200 ml).Their relevant indexes including intravaginal ejaculation latency time(IELT),TCM syndrome score,and clinical general impression of change(CGIC),were recorded before the treatment and after 4-week,8-week treatment.Results After 4-week treatment,IELT,TCM syndrome score,and CGIC were all significantly improved(P all<0.01),and after 8-week treatment,these indexes were also obviously improved(P all<0.01).Amelioration of IELT,TCM syndrome score,and CGIC was much better after 8-week treatment compared with those after 4-week treatment,(P all<0.01).The total effective rate of IELT improvement after 4-week and 8-week treatment were 45.71%(16/35)and 88.57%(31/35)respectively,and the difference was statistically significant(P value<0.01).In this clinical trial,no obvious adverse effects were found in all patients.Conclusion JiaotaiGujing decoction was effective in the treatment of PE with syndrome of Xin-Shen incoordination,but a further study was still needed.

关 键 词：交泰固精汤 早泄 心肾不交证 阴道内射精潜伏期 临床研究 

分 类 号：R698.9[医药卫生—泌尿科学] R277.5[医药卫生—外科学]