舒络饮联合瑞舒伐他汀对代谢综合征患者糖脂代谢的影响  

Effect of Shuluo Yin Combined with Rosuvastatin Calcium on Glucose and Lipid Metabolism of Patients with Metabolic Syndrome

作　　者：童丽娜 汪凌霄[1] TONG Li’na;WANG Lingxiao

机构地区：[1]中国医科大学绍兴医院,浙江绍兴312030

出　　处：《新中医》2021年第17期102-105,共4页New Chinese Medicine

摘　　要：目的:观察舒络饮联合瑞舒伐他汀治疗代谢综合征(MS)临床效果及糖脂代谢情况,旨在为临床MS的治疗方案提供依据。方法:纳入2018年5月—2019年10月收治的MS患者95例为研究对象,将其随机编号1~95号,将奇数患者48例纳入对照组,将偶数患者47例纳入观察组。2组均进行常规治疗,对照组给予瑞舒伐他汀治疗,观察组在对照组基础上联合舒络饮治疗。观察2组中医证候疗效、血糖及胰岛素指标、血脂及用药安全性。结果:与对照组(77.08%)比较,观察组总有效率(93.62%)较高(P<0.05);较治疗前,治疗后2组空腹血糖(FBG)、空腹胰岛素(FINS)及胰岛素抵抗指数(HOMA-IR)均降低,且观察组较对照组低(P<0.05);较治疗前,治疗后2组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)均降低,高密度脂蛋白胆固醇(HDL-C)升高,且观察组改善更显著(P<0.05);2组治疗期间未出现严重不良反应。结论:MS患者在瑞舒伐他汀降脂治疗基础上联合舒络饮治疗可有效调节血糖及血脂水平,促进临床症状的改善,提高临床治疗效果,且用药安全性较高。Objective: To observe the clinical effect of Shuluo Yin combined with rosuvastatin calcium for metabolic syndrome(MS) and glucose and lipid metabolism,so as to provide reference for clinical treatment of MS. Methods:A total of95 cases of MS patients admitted from May 2018 to October 2019 were selected as the study subjects. They were randomly numbered 1 to 95;48 patients with odd numbers were included in the control group,and 47 patients with even numbers were included in the observation group. Both groups were given routine treatment,and the control group was treated with rosuvastatin calcium,and the observation group was additionally treated with Shuluo Yin based on the control group. The curative effect of TCM syndrome, blood glucose and insulin index, blood lipid and safety of medication were observed.Results:Compared with the control group(77.08%),the total effective rate of the observation group(93.62%) was higher(P<0.05);compared with before treatment, fasting blood glucose(FBG), fasting insulin(FINS) and insulin resistance index(HOMA-IR) of both groups after treatment were decreased,and the observation group was lower in comparison with the control group(P<0.05);compared with before treatment,triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) were decreased,while high density lipoprotein cholesterol(HDL-C) was increased in both groups after treatment, and the improvement in the observation group was more significant(P<0.05);there was no severe adverse reaction in both groups during treatment. Conclusion:Based on the lipid-lowering treatment with rosuvastatin calcium,the combination of Shuluo Yin can effectively regulate levels of blood glucose and blood lipid of MS patients, promote the improvement of clinical symptoms,and enhance therapeutic effect in clinic,with high safety of medication.

关 键 词：代谢综合征 舒络饮 瑞舒伐他汀 糖脂代谢 

分 类 号：R589[医药卫生—内分泌]