炔雌醇环丙孕酮片联合补肾活血化瘀汤治疗肾虚血瘀型多囊卵巢综合征临床研究  

Clinical Study on Ethinyl Estradiol Cyproterone Tablets Combined with Bushen Huoxue Huayu Tang for Polycystic Ovary Syndrome of Kidney Deficiency and Blood Stasis Type

作　　者：张帅[1] 吴佩蔚[1] 黄亚哲[1] 胡旭[1] 陈建玲[1] ZHANG Shuai;WU Peiwei;HUANG Yazhe;HU Xu;CHEN Jianling

机构地区：[1]南阳市中心医院生殖医学科,河南南阳473000

出　　处：《新中医》2021年第17期113-117,共5页New Chinese Medicine

基　　金：2018年河南省医学科技攻关计划项目(2018020835)。

摘　　要：目的:观察炔雌醇环丙孕酮片联合补肾活血化瘀汤治疗肾虚血瘀型多囊卵巢综合征(PCOS)的临床疗效。方法:选取86例肾虚血瘀型PCOS患者,按随机数字表法分为观察组及对照组。对照组80例采用炔雌醇环丙孕酮片治疗,观察组86例采用补肾活血化瘀汤联合炔雌醇环丙孕酮片治疗。2组均治疗6个月。比较2组临床疗效,观察2组治疗前后子宫内膜厚度、卵巢体积、窦卵泡数以及性激素水平[血清促卵泡生成激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))、睾酮(T)]变化。治疗后随访1年,观察2组妊娠情况。结果:治疗后,观察组总有效率为83.72%,对照组为63.75%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组子宫内膜厚度均较治疗前上升,卵巢体积、窦卵泡数均较治疗前下降,观察组子宫内膜厚度、卵巢体积均大于对照组,窦卵泡数小于对照组,差异均有统计学意义(P<0.05)。治疗后,2组FSH、T水平均较治疗前下降(P<0.05),LH、E_(2)水平均较治疗前升高(P<0.05),观察组FSH、T水平均低于对照组(P<0.05),LH、E_(2)水平均高于对照组(P<0.05)。治疗期间,2组均未见明显不良反应,差异无统计学意义(P>0.05)。治疗结束后,随访1年,观察组月经周期恢复率、排卵率、受孕率均高于对照组,差异均有统计学意义(P<0.05)。结论:炔雌醇环丙孕酮片联合补肾活血化瘀汤治疗肾虚血瘀型PCOS可提高疗效,调节卵巢功能,改善性激素水平和妊娠情况,用药安全性较高。Objective:To observe the clinical effect of ethinyl estradiol cyproterone tablets combined with Bushen Huoxue Huayu tang for polycystic ovary syndrome(PCOS) of kidney deficiency and blood stasis type.Methods:A total of 86 cases of PCOS patients of kidney deficiency and blood stasis type were divided into the observation group and the control group according to the random number table method.The control group,with 80 cases,was treated with ethinyl estradiol cyproterone tablets,and the observation group was treated with Bushen Huoxue Huayu tang combined with ethinyl estradiol cyproterone tablets.Both groups were treated for six months.The clinical effect in the two groups was compared.Before and after treatment,the changes in endometrial thickness,ovarian volume,number of antral follicle and sex hormone levels including follicle stimulating hormone(FSH),luteinizing hormone(LH),estrogen(E_(2)) and testosterone(T) in serum in the two groups were observed.After treatment,the patients were followed up for one year to observe the pregnancy situation in the two groups.Results:After treatment,the total effective rate was 83.72%in the observation group and 63.75%in the control group,the difference being significant(P<0.05).After treatment,the endometrial thickness in the two groups was increased when compared with that before treatment,and the ovarian volume and number of antral follicle were decreased;the endometrial thickness and ovarian volume in the observation group were larger than those in the control group,and the number of antral follicle was fewer,differences being significant(P<0.05).After treatment,the levels of FSH and T in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of LH and E_(2)were increased(P<0.05);the levels of FSH and T in the observation group were lower than those in the control group(P<0.05),and the levels of LH and E_(2)were higher(P<0.05).During treatment,there was no obvious adverse reaction in the two groups,there being no significance in the di

关 键 词：多囊卵巢综合征 肾虚血瘀型 补肾活血化瘀汤 炔雌醇环丙孕酮片 

分 类 号：R711.75[医药卫生—妇产科学]