芪血颗粒联合二维亚铁治疗小儿缺铁性贫血的临床研究  

Clinical study of Qixue Granules combined with compound ferrous fumarate and vitamin B in treatment of iron deficiency anemia in children

作　　者：崔清彦 陈森[1] CUI Qing-yan;CHEN Sen(Department of Hematology,Tianjin Children’s Hospital,Tianjin 300134,China)

机构地区：[1]天津市儿童医院血液科,天津300134

出　　处：《现代药物与临床》2021年第8期1628-1631,共4页Drugs & Clinic

基　　金：天津市科技计划项目(18JCTPJC36430)。

摘　　要：目的探讨芪血颗粒联合二维亚铁颗粒治疗小儿缺铁性贫血的临床疗效。方法回顾性分析2019年2月—2021年2月在天津市儿童医院进行治疗的106例缺铁性贫血患儿临床资料,根据用药差别将所有患者分为对照组和治疗组,每组各53例。对照组口服二维亚铁颗粒,5 g/次,2次/d。治疗组在对照组基础上口服芪血颗粒,2~7岁,1袋/次,2次/d;8岁以上,1袋/次,3次/d。两组均治疗28 d进行效果比较。观察两组的临床疗效,比较两组临床症状改善时间、贫血指标和铁代谢指标。结果经治疗,治疗组总有效率是98.11%,显著高于对照组的83.02%(P<0.05)。经治疗,治疗组皮肤和黏膜苍白、食欲不振、精神不振、不愿活动、头晕改善时间均显著短于对照组(P<0.05)。经治疗,两组患儿血红蛋白、红细胞平均体积(MCV)、平均血红蛋白量(MCH)、红细胞平均血红蛋白浓度(MCHC)水平均显著增高(P<0.05);且治疗组贫血指标改善优于对照组(P<0.05)。经治疗,两组患儿血清铁蛋白(SF)、血清铁(SI)均较治疗前显著升高,但转铁蛋白受体(sTFR)、总铁结合力(TIBC)水平均显著降低(P<0.05);治疗后,治疗组铁代谢指标改善优于对照组(P<0.05)。结论芪血颗粒联合二维亚铁颗粒治疗小儿缺铁性贫血具有较好临床疗效,可有效改善患儿临床症状和铁代谢指标,有着良好的临床应用价值。Objective To investigate the clinical efficacy of Qixue Granules combined with compound ferrous fumarate and Vitamin B in treatment of iron deficiency anemia in children.Methods Retrospective analysis was performed on the clinical data of 106 children with iron deficiency anemia treated in Tianjin Children’s Hospital from February 2019 to February 2021.All children were divided into control group and treatment group according to medication difference,with 53 cases in each group.Children in the control group were po administered with Compound Ferrous Fumarate and Vitamin B Granules,5 g/time,twice daily.Children in the treatment group were po administered with Qixue Granules on the basis of the control group,2—7 years old,1 bag/time,twice daily,more than age 8 years old,1 bag/time,3 times daily.Children in two groups were treated for 28 d.After treatment,the clinical efficacy was evaluated,and the improvement time of clinical symptoms,anemia index and iron metabolism index were compared between the two groups.Results After treatment,the total effective rate of treatment group was 98.11%,which was significantly higher than that of control group(83.02%)(P<0.05).After treatment,the improvement time of skin and mucosa pallor,loss of appetite,indolence of spirit,unwillingness to activity,and dizziness in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the levels of hemoglobin(Hb),mean RBC volume(MCV),mean hemoglobin volume(MCH),and mean RBC hemoglobin concentration(MCHC)in two groups were significantly increased(P<0.05).After treatment,the improvement of anemia index in treatment group was better than that in control group(P<0.05).After treatment,serum ferrin(SF)and serum iron(SI)in two groups were significantly increased compared with those before treatment,but the levels of transferrin receptor(sTFR)and total iron binding capacity(TIBC)were significantly decreased(P<0.05).After treatment,the improvement of iron metabolism index in treatment group was better than

关 键 词：芪血颗粒 二维亚铁颗粒 缺铁性贫血 临床症状改善时间 血红蛋白 红细胞平均体积 平均血红蛋白量 红细胞平均血红蛋白浓度 血清铁蛋白 血清铁 转铁蛋白受体 总铁结合力 

分 类 号：R985[医药卫生—药品] R977[医药卫生—药学]