热淋清颗粒联合坦索罗辛治疗慢性前列腺炎的临床研究  

Clinical study on Relinqing Granules combined with tamsulosin in treatment of chronic prostatitis

作　　者：孙凤亮[1] 李海波 李贵忠[2] SUN Feng-liang;LI Hai-bo;LI Gui-zhong(Department of Urology,Tianjin Baodi Hospital(Baodi Clinical College of Tianjin Medical University),Tianjin 301800,China;Department of Urology,Beijing Jishuitan Hospital,Beijing 100195,China)

机构地区：[1]天津市宝坻区人民医院(天津医科大学宝坻临床学院)泌尿外科,天津301800 [2]北京积水潭医院泌尿外科,北京100195

出　　处：《现代药物与临床》2021年第8期1659-1663,共5页Drugs & Clinic

基　　金：北京市科技计划项目(Z171100001017133)。

摘　　要：目的探讨热淋清颗粒联合盐酸坦索罗辛缓释胶囊治疗慢性前列腺炎的临床疗效。方法选取2019年10月—2020年1月在天津市宝坻区人民医院就诊的102例慢性前列腺炎患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各51例。对照组口服盐酸坦索罗辛缓释胶囊,0.2 mg/次,1次/d。治疗组患者在对照组治疗的基础上温水冲服热淋清颗粒,8g/次,3次/d。两组患者连续治疗4周。观察两组的临床疗效,采用前列腺炎症症状评分(NIH-CPSI)对患者的病情程度进行评估。使用膀胱测压仪检测两组患者治疗前后尿动力学的改变。对比两组血清γ-干扰素(IFN-γ)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平。结果治疗后,治疗组的总有效率为96.08%,对照组的总有效率为84.31%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组的疼痛评分、排尿症状评分、生活质量评分、NIH-CPSI评分显著降低(P<0.05);治疗后,治疗组的各评分比对照组低,差异有统计学意义(P<0.05)。治疗后,两组的最大尿流率明显升高,膀胱颈长度、最大尿道压力明显降低(P<0.05);治疗后,治疗组的最大尿流率比对照组高,膀胱颈长度、最大尿道压力比对照组低,差异有统计学意义(P<0.05)。治疗后,两组IFN-γ、IL-1β、TNF-α水平明显降低(P<0.05),且治疗组IFN-γ、IL-1β、TNF-α水平降低比对照组更明显(P<0.05)。结论热淋清颗粒联合盐酸坦索罗辛缓释胶囊治疗慢性前列腺炎的疗效确切,可有效控制患者病情,改善尿动力学指标,降低炎症反应,安全性良好。Objective To investigate the clinical efficacy of Relinqing Granules combined with Tamsulosin Hydrochloride Sustained Release Capsules in treatment of chronic prostatitis.Methods Patients(102 cases)with chronic prostatitis in Tianjin Baodi Hospital from October 2019 to January 2020 were randomly divided into control and treatment groups,and each group had 51 cases.Patients in the control group were po administered with Tamsulosin Hydrochloride Sustained Release Capsules,0.2 mg/time,once daily.Patients in the treatment group were po administered with Relinqing Granules on the basis of the control group,8 g/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and the severity of the patients was evaluated by prostatitis symptom score(NIH-CPSI).Bladder manometer was used to detect the changes of urodynamics in the two groups before and after treatment,and the serum levels of IFN-γ,IL-1β,and TNF-α were compared between the two groups.Results After treatment,the total effective rate was 96.08% in the treatment group,and 84.31% in the control group,there was significant difference between two groups(P<0.05).After treatment,the pain,micturition symptoms,quality of life,and NIH-CPSI score of two groups were significantly decreased(P<0.05).After treatment,the pain,micturition symptoms,quality of life and NIH-CPSI score in the treatment group were lower than those in the control group(P<0.05).After treatment,the maximum urinary flow rate were significantly increased,the length of bladder neck and the maximum urethral pressure were significantly decreased(P<0.05).After treatment,the maximum urinary flow rate in the treatment group was higher than that in the control group,but the length of bladder neck and maximum urethral pressure were lower than those in the control group(P<0.05).After treatment,the levels of IFN-γ,IL-1β,and TNF-α in two groups were significantly lower(P<0.05),and the levels of IFN-γ,IL-1β,and TNF-α in the treatment group we

关 键 词：热淋清颗粒 盐酸坦索罗辛缓释胶囊 慢性前列腺炎 病情程度 尿动力学 炎症反应 

分 类 号：R983[医药卫生—药品]