急性肺栓塞恢复期患者焦虑抑郁状态研究  

Evaluation of anxiety/depression state after acute pulmonary embolism

作　　者：郝敏 周苗子[2] 逯勇[1] 杨媛华[1] Hao Min;Zhou Miaozi;Lu Yong;Yang Yuanhua(Department of Respiratory and Critical Care Medicine,Beijing Chaoyang Hospital,Capital Medical University,Key Laboratory of Respiratory and Pulmonary Circulation Disorders,Institute of Respiratory Medicine,Beijing 100020,China;Beijing Geriatric Hospital,Beijing 100095,China)

机构地区：[1]首都医科大学附属北京朝阳医院呼吸与危重症医学科,北京市呼吸和肺循环重点实验室,北京呼吸疾病研究所,北京100020 [2]北京老年医院,北京100095

出　　处：《中国医刊》2021年第10期1075-1078,共4页Chinese Journal of Medicine

基　　金：国家“十三五”重点研发计划(2016YFC1304402)。

摘　　要：目的探究急性肺栓塞恢复期患者的焦虑抑郁状态。方法选取2017年10月至2018年10月于首都医科大学附属北京朝阳医院复诊的急性肺栓塞恢复期患者共70例。所有患者均采集一般资料,并完成广泛性焦虑抑郁量表-7(generalized anxiety disorder-7,GAD-7)、健康问卷抑郁症状群量表-9(patient health questionnaire-9,PHQ-9)、Brog呼吸困难评分及肺灌注扫描并计算肺灌注缺损率(pulmonary vascular obstruction,PVO),根据PVO分为无残余血栓组(PVO=0)32例和残余血栓组(PVO>0)38例。70例患者的GAD-7评分与德国GAD-7常模进行比较,PHQ-9评分与中国PHQ-9常模进行比较。结果70例患者的GAD-7评分与德国GAD-7常模比较差异无显著性(P>0.05),焦虑状态检出率为12.9%,高于德国GAD-7常模的5%,差异有显著性(χ2=9.098,P<0.05);PHQ-9评分与中国PHQ-9常模比较差异无显著性(P>0.05),抑郁状态检出率为14.3%,高于中国PHQ-9常模的7%,差异有显著性(χ2=5.708,P<0.05)。残余血栓组患者GAD-7阳性检出率高于德国GAD-7常模,无残余血栓组患者PHQ-9阳性检出率高于中国PHQ-9常模,差异均有显著性(P<0.05),残余血栓组的GAD-7及PHQ-9评分及阳性检出率与无残余血栓组比较,差异均有显著性(P>0.05)。Brog评分与GAD-7、PHQ-9、PVO%无相关性(P>0.05)。结论急性肺栓塞患者恢复期患者焦虑和抑郁发生率高,临床医生应密切关注并给予适当干预。Objective To evaluate the anxiety/depression state after acute pulmonary embolism.Method 70 acute pulmonary embolism patients were enrolled to accomplish the GAD-7 questionnaires,PHQ-9 questionnaires,Borg scale and lung perfusion scan during October 2017 to October 2018 from Department of Respiratory and Critical Care Medicine,Beijing Chaoyang Hospital,Capital Medical University.According to the lung perfusion scan to calculate PVO and patients were divided into two groups:no residual thrombi group(PVO=0,32cases)and residual thrombi group(PVO>0,38cases).Result Acute pulmonary embolism group had higher detection rate of GAD-7 comparing to the German general group and of PHQ-9 comparing to the Chinese general group,and the differences had statistical significance(P<0.05).PVO>0 group had higher GAD-7 detection rate comparing to the German general group(P<0.05),while PVO=0 group had higher PHQ-9 detection rate comparing to the Chinese general group(P<0.05).The difference of GAD-7 and PHQ-9 between PVO>0 group and PVO=0 group had no statistical significance(P>0.05).The severity of Borg scale had no significant relevance with GAD-7,PHQ-9 and PVO%(P>0.05).Conclusion The acute pulmonary embolism patients had significantly higher prevalence of anxiety and depression which need more attention and timely intervention from physician.

关 键 词：急性肺栓塞 残余血栓 焦虑 抑郁 

分 类 号：R563.5[医药卫生—呼吸系统]