聚乙二醇干扰素α序贯联合核苷类药物治疗高病毒载量e抗原阳性乙型肝炎的疗效  

Efficacy of PeginterferonαSequential Combined with Nucleoside Drugs in the Treatment of High Viral Load e Antigen Positive Hepatitis B

作　　者：王明杰 秦玉杰 WANG Ming-jie;QIN Yu-jie(Department of Infectious Diseases,Tianjin Binhai New Area People's Hospital,Tianjin 300280,China)

机构地区：[1]天津市滨海新区海滨人民医院感染性疾病科,天津300280

出　　处：《医学信息》2021年第19期107-109,共3页Journal of Medical Information

摘　　要：目的研究聚乙二醇干扰素α序贯联合核苷类药物治疗高病毒载量e抗原阳性乙型肝炎的临床疗效。方法选取2019年8月-2020年4月我院诊治的68例高病毒载量e抗原阳性乙型肝炎患者为研究对象,采用随机数字表法分为对照组和观察组,各34例。对照组采用聚乙二醇干扰素α序贯治疗,观察组在对照组基础上联合核苷类药物治疗,比较两组临床治疗总有效率、HBV-DNA转阴率、HBeAg转阴率、HBsAg清除率、肝功能指标变化以及临床不良反应发生情况。结果观察组临床治疗总有效率为94.11%,高于对照组的82.35%,差异有统计学意义(P<0.05);观察组HBV-DNA转阴率、HBeAg转阴率、HBsAg清除率均大于对照组,差异有统计学意义(P<0.05);两组治疗后ALT、TBIL均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为14.70%,与对照组的11.76%比较,差异无统计学意义(P>0.05)。结论聚乙二醇干扰素α序贯联合核苷类药物治疗高病毒载量e抗原阳性乙型肝炎效果确切,可提高治疗总有效率,提升HBV-DNA和HBeAg转阴率以及HBsAg清除率,改善肝功能,且不会增加不良反应。Objective To study the clinical efficacy of peginterferonαsequential combined with nucleoside drugs in the treatment of high viral load e antigen positive hepatitis B.Methods Totally 68 patients with high viral load e antigen positive hepatitis B were selected from August 2019 to April 2020,and were divided into control group and observation group by random number table method,with 34 cases in each.The control group was treated with polyethylene glycol sequential therapy,and the observation group was treated with nucleoside drugs on the basis of the control group,the total effective rate,negative rate of HBV-DNA,negative rate of HBeAg,clearance rate of HBsAg,changes of liver function index and clinical adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.11%,which was higher than that 82.35%of the control group,and the difference was statistically significant(P<0.05);the negative rate of HBV-DNA,the negative rate of HBeAg and the clearance rate of HBsAg in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05);after treatment,ALT and TBIL in the two groups were lower than before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05);the incidence of adverse reaction in the observation group was 14.70%,which was comared with 11.76%of the control group,the difference was not statistically significant(P>0.05).Conclusion Peginterferonαsequential combined with nucleoside drugs in the treatment of high viral load e antigen positive hepatitis B is effective,which can improve the total effective rate of treatment,enhance HBV-DNA and HBeAg negative conversion rate and HBsAg clearance rate,and improve liver function,and will not increase the adverse reaction.

关 键 词：聚乙二醇干扰素Α 核苷类药物 乙型肝炎 高病毒载量 E抗原阳性 

分 类 号：R512.62[医药卫生—内科学]