3D打印技术在皮肤癌近距离放疗中的初步应用  

Preliminary application of 3D printing technology in brachytherapy for skin cancer

作　　者：薛涛[1] 何晓阳 孙云川[1] 刘光波[1] 王斌[1] 王佩烨 赵建勇[3] XUE Tao;HE Xiaoyang;SUN Yunchuan;LIU Guangbo;WANG Bin;WANG Peiye;ZHAO Jianyong(Department of Radiation Oncology,Cangzhou Hospital of Integrated TCM-WM,Cangzhou 061001,China;Department of Nephrology,Cangzhou People's Hospital,Cangzhou 061001,China;3D Printing Center,Cangzhou Hospital of Integrated TCMWM,Cangzhou 061001,China)

机构地区：[1]河北省沧州中西医结合医院放射物理治疗科,河北沧州061001 [2]沧州市人民医院肾内科,河北沧州061001 [3]河北省沧州中西医结合医院3D打印中心,河北沧州061001

出　　处：《中国医学物理学杂志》2021年第9期1068-1071,共4页Chinese Journal of Medical Physics

摘　　要：目的:探讨3D打印技术在皮肤癌高剂量率近距离治疗个体化施源器模板制作中的应用。方法:根据1例基底细胞皮肤癌患者的定位CT图像进行术前计划设计,然后根据患者轮廓和术前计划中预设管道位置完成3D模板打印。将打印好的模板置于病灶处并加以固定,再次进行CT扫描,将两次的CT图像进行融合匹配,以确定管道位置重合程度。结果:3D打印模板与患者外轮廓高度贴合,实际治疗中,3D打印模板中施源器管道位置可与预计划中的施源器管道位置完成匹配重合,提高了靶区覆盖率。结论:对于位置轮廓曲面角度大的皮肤癌病变,根据术前计划进行3D打印模板辅助近距离治疗可使病灶较好地达到处方剂量。临床疗效与不良反应尚需进一步观察。Objective To explore the application of 3D printing technology in the template manufacture of individualized source applicator for high-dose-rate brachytherapy of skin cancer.Methods The preoperative plan was designed based on the positioning CT image of a patient with basal cell carcinoma,and then the 3D template printing was completed according to the patient's profile and the preset catheter position in the preoperative plan.After the printed template was placed at the focus and fixed,CT scan was conducted again.The two CT images were fused and matched to determine the degree of coincidence of the catheter position.Results The 3D printed template highly fitted the patient's profile,and the source applicator catheter position in the 3D printed template matched and coincided with the planned catheter position,which increased the target coverage rate.Conclusion For the skin cancer lesions with large facial contour and curved surface angle,the brachytherapy using 3D printed template which is designed according to preoperative plan can make the lesion receive the prescription dose better.However,clinical therapeutic effect and side effects need to be further observed.

关 键 词：皮肤癌 3D打印 术前计划 近距离治疗 

分 类 号：R319[医药卫生—基础医学] R815.2