锁骨下动脉、颈总动脉和椎动脉分叉处血流动力学数值模拟  

Numerical simulation for hemodynamics at the bifurcations of subclavian artery,common carotid artery and vertebral artery

作　　者：赵洪明 彭红梅[1] 张东威[2] 陈阳 ZHAO Hongming;PENG Hongmei;ZHANG Dongwei;CHEN Yang(College of Mathematics and Physics,Inner Mongolia Minzu University,Tongliao 028043,China;Department of Neurology,Affiliated Hospital of Inner Mongolia Minzu University,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学数理学院,内蒙古通辽028043 [2]内蒙古民族大学附属医院神经内科,内蒙古通辽028000

出　　处：《中国医学物理学杂志》2021年第9期1151-1157,共7页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(11362015,81641127);内蒙古自治区自然科学基金(2013MS0113,2018LH01005)。

摘　　要：目的:探讨锁骨下动脉、颈总动脉和椎动脉分叉处的血流动力学特性,分析该处发生血管狭窄引起大脑供血不足的血流动力学原因。方法:采用内蒙古民族大学附属医院神经内科提供的CT数据,应用医学建模软件MIMICS20.0将患者二维CT数据进行三维血管重建,经过网格划分及边界条件设置后导入计算流体力学软件FLUENT14.5中。计算和分析不同血液入口速度的锁骨下动脉、颈总动脉和椎动脉分叉处的血流动力学特性。结果:在血液入口速度不同的情况下,锁骨下动脉、颈总动脉和椎动脉分叉处的血液流场分布、血液压力分布和血管壁面切应力分布有显著变化。在血液入口速度增大时,锁骨下动脉分叉处和颈总动脉分叉处的血液流速快、血管壁压力大,颈总动脉内侧血管壁面切应力大,但锁骨下动脉分叉处和颈总动脉分叉处血管壁面切应力数值和变化幅度小,属于低切应力区。结论:通过血流动力学数值模拟研究,分析锁骨下动脉、颈总动脉和椎动脉分叉处易发生粥样斑块病变导致大脑供血不足的血流动力学原因。Objective To explore the hemodynamic characteristics at the bifurcations of subclavian artery,common carotid artery and vertebral artery,and to analyze the hemodynamic reason for the insufficiency of the cerebral blood supply caused by vascular stenosis occurred here.Methods The CT data provided by Department of Neurology,Affiliated Hospital of Inner Mongolia Minzu University were used in the study.The medical modeling software MIMICS 20.0 was used to reconstruct the two-dimensional CT date into three-dimensional blood vessel,and after grid division and boundary condition setting,it was imported into computational fluid dynamics software FLUENT14.5.The hemodynamic characteristics at the bifurcations of subclavian artery,common carotid artery and vertebral artery with different blood inlet velocities were calculated and analyzed.Results The distributions of blood flow field,blood pressure and wall shear stress at the bifurcations of subclavian artery,common carotid artery and vertebral artery changed significantly when the blood inlet velocity was different.With the increasing blood inlet velocity,the blood flow velocities at subclavian artery bifurcation and common carotid artery bifurcation were faster,and the vessel wall pressure at the bifurcations was increased,and the shear stress of the medial common carotid artery was larger,but the shear stress and change range of the vessel wall at subclavian artery bifurcation and common carotid artery bifurcation were small,indicating that subclavian artery bifurcation and common carotid artery bifurcation still belonged to the low shear stress area.Conclusion The analysis on the hemodynamic reasons for the insufficiency of the cerebral blood supply caused by atherosclerotic plaque at the bifurcation of subclavian artery,common carotid artery and vertebral artery bifurcate are realized through the hemodynamic numerical simulation.

关 键 词：锁骨下动脉 颈总动脉 椎动脉 医学建模 血流动力学 计算流体力学 

分 类 号：R318.01[医药卫生—生物医学工程] O357.1[医药卫生—基础医学]