MDR1基因多态性在自身免疫性疾病精准诊疗中的应用  

The applications of MDR1 polymorphism in precision diagnosis and treatment of autoimmune disease

作　　者：郭力维 李长天 Guo Liwei;Li Changtian(Department of Physiology,Medical College,Hexi University,Zhangye 734000,Gansu,China;School of Basic Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu,China)

机构地区：[1]河西学院医学院生理学教研室,甘肃张掖734000 [2]甘肃中医药大学基础医学院,甘肃兰州730000

出　　处：《生物医学转化》2021年第3期57-61,共5页Biomedical transformation

基　　金：甘肃省高等学校创新能力提升项目(2019A-074)。

摘　　要：自身免疫性疾病(AutoimmuneDisease,AID)是因机体对自身抗原发生反应,免疫稳态失衡而引起自身组织损伤的疾病状态,与自身抗原、免疫调节异常、交叉抗原、遗传因素有关。AID精准诊疗是目前AID临床管理的新方向。多药耐药-1(Multi-drugResistance-1,MDR1)基因多态性在AID的诊断和鉴别诊断,确定疾病活动、严重程度和并发症,治疗方案选择及疗效预测等方面有良好的应用前景,并将有助于实现临床AID患者个体化管理。本文就MDR1基因多态性在常见AID精准诊疗中应用的研究进展做一综述。Autoimmune disease(AID)is a disease state of self-tissue damage caused by the imbalance of immune homeostasis due to the body's response to self antigens.It is related to self antigens,abnormal immune regulation,cross antigens and genetic factors.The accurate diagnosis and treatment are a new development trend for AID clinical management.MDR1 polymorphism has shown better future applications in several areas,such as diagnosis and differential diagnosis of AID.The determination of disease activity,severity and complications.The selection for treatments in AID and prediction of therapeutic effects.MDR1 polymorphism will also contribute to personalized clinical management of AID.

关 键 词：自身免疫性疾病 多药耐药基因1 基因多态性 精准医学 

分 类 号：R593.2[医药卫生—内科学] R459.9[医药卫生—临床医学]