体外反搏联合运动治疗对冠状动脉闭塞病变患者炎症因子及心功能的影响  

The influence of external counterpulsation combined with exercise therapy on the level of inflammatory factors and the cardiac function in patients with coronary artery occlusion

作　　者：杜峰[1] 毛华[1] 郭艳丽[1] 刘廷筑[1] 李羚[1] 沙忠心[1] 黎姗姗[1] 郭美琴 罗坤 Du Feng(The first people's hospital of Guiyang,Guiyang,Guizhou,550002,China)

机构地区：[1]贵阳市第一人民医院,贵州贵阳550002

出　　处：《齐齐哈尔医学院学报》2021年第15期1301-1304,共4页Journal of Qiqihar Medical University

基　　金：贵州省科技厅科学技术基金项目(黔科合J字【2013】2015号);贵阳市科技局科技计划项目(筑科合【2018】1-26号);贵阳市高层次创新型青年卫生人才项目(【2017】筑卫科技合同字第008号);贵阳市人才创新创业资助项目(筑人才办合同字【2014】第12号)。

摘　　要：目的研究体外反搏联合运动治疗对冠脉闭塞病变患者心功能及Hs-CRP、MPO、moesin的影响。方法选择2018年2月—2020年1月本院收治的56例冠心病患者作为研究对象,所有患者均经冠脉造影结果证实至少有一支冠状动脉(前降支、回旋支、右冠状动脉)完全闭塞,按患者治疗方案不同归入对照组(常规药物治疗,19例)和治疗组(常规药物治疗加运动治疗及体外反搏,37例)。于接受治疗前后分别采用免疫增强比浊法检测其NT-BNP,采用酶联免疫吸附试验(ELISA)检测患者血清moesin抗体、Hs-CRP、MPO,并对其moesin抗体阳性检出率及OD检测值进行分析,心脏超声检查其EF值、左室舒张末期内径和左室收缩末期内径。结果两组患者治疗前后moesin抗体阳性检出率、OD值、NT-BNP、Hs-CRP、MPO、EF值、左室舒张末期内径和左室收缩末期内径比较,差异无统计学意义(P>0.05),但治疗后两组的组OD检测值、NT-BNP、Hs-CRP、MPO、左室舒张末期内径和左室收缩末期内径交治疗前下降,治疗组优于对照组,差异均具有统计学意义(P<0.05);两组患者治疗后EF值较治疗前升高,治疗组优于对照组,差异具有统计学意义(P<0.05)。结论体外反搏联合运动治疗可能降低冠心病闭塞病变患者的炎症因子水平及Moesin抗体表达;体外反搏联合运动治疗可能提升冠心病闭塞病变患者的心功能。Objective To study the effect of external counterpulsation combined with exercise therapy on cardiac function,Hs-CRP,MPO and moesin in patients with coronary occlusive disease.Methods The 56 patients with coronary heart disease those who admitted to our hospital from February 2018 to January 2020 were enrolled as study subjects,and all of the patients were confirmed by coronary angiography that at least one coronary artery(anterior descending artery,circumflex artery,and right coronary artery)was completely occluded.According to the different treatment plans of the patients,they were classified into the control group(conventional drug treatment)and the treatment group(conventional medication plus exercise therapy and external counterpulsation).Before and after treatment,the NT-BNP was detected by immunoenhancement turbidimetric method,and the serum moesin antibody,Hs-CRP and MPO of the selected candidates were detected by enzyme-linked immunosorbent assay(ELISA);and the positive detection rate of moesin antibody and OD were analyzed.The value of heart EF,left ventricular end diastolic diameter and left ventricular end systolic diameter were examined by cardiac ultrasound.Results There were no significant difference between the two groups before and after treatment in the aspects of the positive detection rate of moesin antibody,OD value,NT-BNP,Hs-CRP,MPO,the value of EF,left ventricular end-diastolic diameter and left ventricular end-systolic diameter(P>0.05).However,the OD detection value,NT-BNP,Hs-CRP,MPO,left ventricular end-diastolic diameter and left ventricular end-systole of the two groups were decreased compared with those before the treatment,and the treatment group was better than the control group(P<0.05).After treatment,the value of heart EF in both two groups were higher than those before treatment,and the treatment group was better than the control group(P<0.05).Conclusions External counterpulsation combined with exercise therapy may reduce the level of inflammatory factors and moesin antibody expre

关 键 词：体外反搏 运动治疗 冠脉闭塞 膜突蛋白抗体 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]