5-磺基水杨酸固液相平衡研究  

Measurement and correlation of 5-sulfosalicylic acid dihydrate solubility in different solvents

作　　者：郝红英[1] 田恒运[1] 任凯文 丁少羊 HAO Hong-ying;TIAN Heng-yun;REN Kai-wen;DING Shao-yang(Medical School,HuangHe Science and Technology College,Zhengzhou 450063,China)

机构地区：[1]黄河科技学院医学院,河南郑州450063

出　　处：《化学研究与应用》2021年第9期1660-1665,共6页Chemical Research and Application

基　　金：河南省科技厅科技攻关项目(172102310310);河南省高等学校青年骨干教师培养计划(2018GGJS177);河南省重点学科工程项目(教高〔2018〕119号);黄河科技学院创新创业示范课(JCXK201718).

摘　　要：采用动态法测定了5-磺基水杨酸在甲醇、乙醇、正丙醇、正丁醇和水中的溶解度,并采用Van’t Hoff方程、Apelblat方程与λh方程对溶解度数据进行关联,结果表明,5-磺基水杨酸在五种溶剂中的溶解度均随温度的升高而增大,在甲醇中的溶解度最大、水中最小,实验中的二元体系的关联结果与实验值相吻合,为5-磺基水杨酸纯化工艺提供了一定的理论指导和依据。The solubility of 5-sulfosalicylic acid in methanol,ethanol,n-propanol,n-butanol and water was measured by dynamic method in this paper.The results showed that the solubility of 5-sulfosalicylic acid in the above five solvents increased with the increase of temperature.5-sulfosalicylic acid had the highest solubility in methanol and the lowest in water.The solubility data were correlated by Van't Hoff equation,Apelblat equation andλh equation and the results showed the correlation results of the binary systems in the experiments were consistent with the experimental values,which provided a theoretical basis for the purification process of 5-sulfosalicylic acid.

关 键 词：5-磺基水杨酸 溶解度 动态法 固液相平衡 模型 

分 类 号：TQ013.1[化学工程]