经心尖人工腱索植入器械的优化设计与分析  

Optimal Design and Analysis of Transapical Artificial Chordal Implantation Device

作　　者：崔赛辉 王皓辰 赵展[1] 宋成利[1] 王伟 CUI Saihui;WANG Haochen;ZHAO Zhan;SONG Chengli;WANG Wei(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai,200093;Naval Special Medical Center,Shanghai,200433)

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]海军特色医学中心,上海200433

出　　处：《生物医学工程学进展》2021年第3期130-133,137,共5页Progress in Biomedical Engineering

基　　金：国家自然科学基金资助项目(51735003);上海市科研计划项目(18441900200);中国博士后基金站前特别资助项目(2019TQ0203)。

摘　　要：目的针对Ⅱ型中度二尖瓣反流患者,优化设计人工腱索的植入器械,同时对腱索的固定方式进行实验研究。方法搭建二尖瓣叶撕脱力实验平台,测量分析3种人工腱索固定方式下的最大撕脱力,并通过有限元分析结果加以验证。结果人工腱索加垫片的固定方式可承受更大的纵向撕脱力,最大撕脱力提高约47.4%(A2瓣叶)、71.9%(P2瓣叶),加垫片的方法减少了二尖瓣叶表面的应力集中。结论经优化设计的人工腱索植入器械,可实现瓣叶的捕获夹持和人工腱索的施放,避免了瓣叶撕裂保证了术后效果的维持。Objective To optimize the current design of chordal implant devices and improve its efficacy on the treatment of type II mitral regurgitation diseases,and to investigate the fixation method of the chordae.Methods An experimental platform was developed to measure the maximum avulsion force of the pig mitral leaflet with three fixation modes of the chordae.The results were then validated with finite element analysis.Results The results indicated that the fixation mode of artificial chordae with gasket can withstand greater longitudinal chordal avulsion force,and the maximum avulsion force is increased by about 47.4%(A2 valve leaflet)and 71.9%(P2 valve leaflet).The method of adding a gasket reduces the stress concentration on the surface of mitral leaflet.Conclusion The optimized design of the artificial chordal implant device can realize the capture and clamping of the valve leaflet and the release of the artificial chordae,avoiding the occurrence of valve leaflet tearing and ensuring the maintenance of the postoperative effects.

关 键 词：二尖瓣反流 人工腱索 优化设计 撕脱力 

分 类 号：R318[医药卫生—生物医学工程]