黄体酮胶囊联合滋阴助阳方治疗多囊卵巢综合征的临床研究  

Clinical study of Progestin capsule Combined with Nourishing Yin and helping Yang prescription in the Treatment of Polycystic ovary syndrome

作　　者：黄有运 贾林英 Huang Youyun;Jia Linying(Department of Traditional Chinese Medicine,Zhejiang Kangjing Hospital,Hangzhou 310000,China)

机构地区：[1]浙江康静医院中医科,浙江杭州310000

出　　处：《实用妇科内分泌电子杂志》2021年第8期47-50,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探究黄体酮胶囊联合滋阴助阳方治疗多囊卵巢综合征(PCOS)的临床疗效。方法选取500例多囊卵巢综合征患者,采用随机数字表法将其分为研究组与对照组,各250例。对照组给予黄体酮胶囊进行治疗,研究组给予滋阴助阳方联合黄体酮胶囊进行治疗,比较两组治疗前后血清激素水平、中医症状评分、子宫恢复情况、妊娠率及排卵率。结果治疗前,两组患者血清促黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E_(2))、睾酮(T)及抗苗勒管激素(AMH)水平比较,差异无统计学意义(P>0.05);治疗后,研究组LH、FSH、T、AMH水平均显著低于对照组,E_(2)水平显著高于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者中医症状评分比较,差异无统计学意义(P>0.05);治疗后,研究组患者中医临床症状评分明显低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患者子宫螺旋动脉搏动指数(PI)、阻力指数(RI)、子宫内膜厚度比较,差异无统计学意义(P>0.05);治疗后,研究组PI、RI均显著低于对照组,子宫内膜厚度显著厚于对照组,差异具有统计学意义(P<0.05)。治疗后,研究组妊娠155例,妊娠率为62.00%,排卵207例,排卵率为82.80%;对照组妊娠120例,妊娠率为48.00%,排卵175例,排卵率为70.00%。研究组妊娠率、排卵率均显著高于对照组,差异具有统计学意义(χ^(2)=9.90、11.36,P<0.05)。结论黄体酮胶囊联合滋阴助阳方治疗多囊卵巢综合征能够有效调节患者的激素分泌水平,改善PI、RI和增加子宫内膜厚度,提高妊娠率和排卵率。具有重要意义。Objective To explore the clinical effect of progesterone capsule combined with Nourishing Yin and helping Yang prescription on polycystic ovary syndrome(PCOS).Methods 500 patients with polycystic ovary syndrome were randomly divided into study group and control group with 250 cases in each group.The control group was treated with progestin capsule,and the research group was treated with Nourishing Yin and helping Yang combined with progestin capsule.The serum hormone levels,TCM symptom scores,uterine recovery,pregnancy rate and ovulation rate before and after treatment were compared between the two groups.Results Before treatment,there were no significant differences in serum luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E_(2)),testosterone(T)and anti-Mullerian hormone(AMH)levels between 2 groups(P>0.05).After treatment,the levels of LH,FSH,T and AMH in the study group were significantly lower than those in the control group,and the level of E_(2)was significantly higher than that in the control group,with statistical significance(P<0.05).Before treatment,there was no statistical significance in TCM symptom score between 2 groups(P>0.05);After treatment,the score of TCM clinical symptoms in the study group was significantly lower than that in the control group,with statistical significance(P<0.05).Before treatment,there were no significant differences in uterine spiral artery pulse index(PI),resistance index(RI)and endometrial thickness between 2 groups(P>0.05).After treatment,PI and RI in the study group were significantly lower than those in the control group,and endometrial thickness was significantly thicker than that in the control group,with statistical significance(P<0.05).After treatment,the pregnancy rate was 62.00%in 155 cases and ovulation rate was 82.80%in 207 cases.In the control group,there were 120 cases of pregnancy,the pregnancy rate was 48.00%,and 175 cases of ovulation,the ovulation rate was 70.00%.The pregnancy rate and ovulation rate in the study group were significantly

关 键 词：多囊卵巢综合征 黄体酮胶囊 滋阴助阳方 激素水平 中医症状 子宫内膜 

分 类 号：R711.75[医药卫生—妇产科学]