探索中老年男性骨量减少和骨质疏松的相关因素  

Study on the related factors of decreased bone content and osteoporosis in middle-age and aged men

作　　者：吴苗 唐兰 王钰麒 钟立[2] 刘兆海[2] 彭斌[1] WU Miao;TANG Lan;WANG Yuqi;ZHONG Li;LIU Zhaohai;PENG Bin(School of Public Health and Management, Chongqing Medical University, Chongqing 400016;The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China)

机构地区：[1]重庆医科大学公共卫生与管理学院,重庆400016 [2]重庆医科大学附属第一医院,重庆400016

出　　处：《中国骨质疏松杂志》2021年第9期1279-1282,1315,共5页Chinese Journal of Osteoporosis

基　　金：重庆市卫健委课题(2017MSXM007);国家重点研发项目(重大慢病流行病学监测大数据平台构建和关键技术研究)(2018YFC1311700)。

摘　　要：目的探索中老年男性骨量减少和骨质疏松的相关因素,为防治骨量减少发展为骨质疏松提供参考。方法选取2017年1月1日至2020年8月31日在某三甲医院健康体检的中老年男性为研究对象。测量空腹血糖、高密度脂蛋白等生化指标,用双能X线骨密度仪测量腰椎和髋关节骨密度。结果单因素Logistic回归分析发现,BMI、腰围、血糖和高密度脂蛋白有统计学意义(P<0.05)。偏瘦、血糖为疾病进展的危险因素;适度肥胖和高密度脂蛋白为疾病进展的保护因素。多因素Logistic回归发现,BMI、血糖为疾病进展的相关因素,且差异有统计学意义。与正常BMI相比,偏瘦为疾病进展的危险因素,适度肥胖为该病进展的保护因素;血糖控制较差的患者疾病进展风险是血糖正常人群的1.4倍,且差异有统计学意义。结论年龄、BMI、腰围、血糖和高密度脂蛋白为骨量减少进展为骨质疏松的相关因素,其中BMI和血糖可能为疾病进展的综合因素。在预防骨量减少进展为骨质疏松时,需综合考虑各种因素。Objective To explore the related factors of decreased bone content and osteoporosis in middle-aged and aged men,so as to provide reference for the prevention and development of decreased bone content and osteoporosis.Methods Middle-aged and elderly men who had physical examination in a third-grade hospital from January 1,2017 to August 31,2020 were selected as the study subjects.Fasting blood glucose,high-density lipoprotein,and other biochemical indexes were measured.Bone mineral density of the lumbar spine and hip joint was measured with dual-energy X-ray absorptiometry.Results Univariate logistic regression analysis showed that BMI,waist circumference,blood glucose,and high-density lipoprotein had statistical significance(P<0.05).Underweight and blood glucose were risk factors for disease progression.Moderate obesity and high-density lipoprotein were protective factors for disease progression.Multiple logistic regression showed that BMI and blood glucose were related factors of disease progression,and the difference was statistically significant.Compared to normal BMI,lean body mass was a risk factor for disease progression,while moderate obesity was a protective factor for disease progression.Patients with poor blood glucose control had 1.4 times high risk of disease progression compared to those with normal blood glucose control,and the difference was statistically significant.Conclusion Age,BMI,waist circumference,blood glucose,and high-density lipoprotein are related factors for the progression of bone content reduction to osteoporosis.Among those,BMI and blood glucose may be comprehensive factors for disease progression.It is necessary to consider all kinds of factors when preventing bone content reduction from progressing to osteoporosis.

关 键 词：骨含量减少 骨质疏松 骨密度 LOGISTIC回归 

分 类 号：R681[医药卫生—骨科学]