氨氯地平贝那普利片治疗自由双联降压未达标的2级高血压患者动态血压评价  

Effect of amlodipine-benazepril tablets on ambulatory blood pressure of grade 2 essential hypertension patients uncontrolled by free combination of two antihypertensive drugs

作　　者：张子渠 刘勇[1] 李经纬 王亚丽 翟羽筠 ZHANG Ziqu;LIU Yong;LI Jing-wei;WANG Yali;ZHAI Yujun(Department of Cardiology,Zigong Third People′s Hospital,Zigong 643020,China;Department of Cardiology,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Cheng-du 610075,China;不详)

机构地区：[1]自贡市第三人民医院心内科,四川自贡643020 [2]成都中医药大学附属医院心内科,成都610075

出　　处：《实用医学杂志》2021年第18期2375-2379,共5页The Journal of Practical Medicine

基　　金：四川省医学会立项课题(编号:川学会医字[2020]352号-2019TG10);四川省中医药管理局立项课题(编号:川中医药函(2020)196号-439)。

摘　　要：目的评价氨氯地平贝那普利片(Ⅱ)[氨贝片(Ⅱ)]治疗自由双联降压未达标的2级原发性高血压病(EH)患者的降压幅度、动态血压(ABPM)达标率和可行性路径。方法经ABPM证实未达标的93例患者,予氨贝片(Ⅱ)治疗4周后评价ABPM降压幅度及血压达标率。结果氨贝片(Ⅱ)治疗后ABPM达标率为35.5%,总有效率72%,无效率28%;24 h MBP[(140.76±15.62)/(89.50±9.86):(126.00±12.05)/(79.90±7.58)]、dMBP[(142.56±15.98)/(90.94±10.68):(127.50±11.95)/(81.12±7.46)]、nMBP[(134.90±17.26)/(84.24±9.42):(121.04±14.29)/(76.00±10.14)]、24 h血压负荷值均低于治疗前(P<0.01)且安全、副作用轻。结论氨贝片(Ⅱ)能安全有效降低患者动态血压幅度(平均14.76/9.60 mmHg)、增加1/3以上患者的ABPM达标,说明其作为自由双联降压未达标2级EH患者的治疗路径能切实获益。Objective To evaluate the anti-hypertensive amplitude,the compliance rate of ambulatory blood pressure monitoring(ABPM),and feasible path of amlodipine-benazepril tablets(Ⅱ)[AMBE tablets(Ⅱ)]in the treatment of grade 2 essential hypertension(EH)patients uncontrolled by free combination of two antihypertensive drugs.Methods A total of 93 patients who failed to meet the standard confirmed by ABPM were treated with AMBE tablet(Ⅱ)for 4 weeks,and the antihypertensive amplitude and the compliance rate of ABPM were evaluated.Results After treatment with AMBE tablets(Ⅱ),the compliance rate of ABPM was 35.5%,with a total effective rate of 72%and ineffective rate of 28%.The results of 24 h MBP[(140.76±15.62)/(89.50±9.86)vs.(126.00±12.05)/(79.90±7.58)],dMBP[(142.56±15.98)/(90.94±10.68)vs.(127.50±11.95)/(81.12±7.46)],and nMBP[(134.90±17.26)/(84.24±9.42)vs.(121.04±14.29)/(76.00±10.14)]were obtained.The 24 h blood pressure load value was significantly lower than that before treatment(P<0.01),and it was safe and had mild side effects.Conclusion AMBE tablets(Ⅱ)can safely and effectively reduce the ambulatory blood pressure range of patients(an average of 14.76/9.60 mmHg),and enhance the compliance rate of ABPM in more than 1/3 patients,indicating that it could be served effectively as a treatment path for grade 2 EH patients who failed to meet the standard of free dual antihypertensive therapy.

关 键 词：氨氯地平贝那普利片(Ⅱ) 单片复方制剂 自由双联降压治疗 原发性高血压 疗效 动态血压达标率 

分 类 号：R544.1[医药卫生—心血管疾病]