分析地屈孕酮对诊刮术后围绝经期排卵障碍性异常子宫出血疗效的影响  

To analyze the effect of Dydrogesterone on Perimenopausal patients with abnormal uterine Bleeding caused by Ovulation barrier after Curettage

作　　者：章靖一[1] Zhang Jingyi(Department of Gynecology,Jiangyin People's Hospital,Jiangyin 214400,China)

机构地区：[1]江阴市人民医院妇科,江苏江阴214400

出　　处：《实用妇科内分泌电子杂志》2021年第9期23-26,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析地屈孕酮对诊刮术后围绝经期排卵障碍性异常子宫出血患者疗效的影响。方法选取69例围绝经期排卵障碍性异常子宫出血患者,按照诊刮术后不同后续治疗方式分为A组、B组与C组,每组23例。A组行诊刮术后因拒绝后续药物治疗选择期待处理,B组行诊刮术后采用地屈孕酮全周期治疗,C组行诊刮术后采用地屈孕酮后半周期治疗,比较三组患者子宫内膜厚度、术后不规则出血率及生活质量。结果治疗前,三组患者子宫内膜厚度比较,差异无统计学意义(P>0.05);治疗后,B组、C组患者子宫内膜厚度明显薄于A组,差异具有统计学意义(P<0.05),而C组和B组子宫内膜厚度比较,差异无统计学意义(P>0.05)。E组、C组患者不规则出血率分别为34.8%、8.7%,均明显低于A组的82.6%,差异有统计学意义(P<0.05),C组患者不规则出血率低于B组,差异有统计学意义(P<0.05)。B组、C组患者躯体功能、生理机能、总体健康评分均明显高于A组,差异有统计学意义(P<0.05);B组、C组躯体功能、生理机能、总体健康评分比较,差异无统计学意义(P>0.05)。结论针对围绝经期排卵障碍性异常子宫出血患者,临床给予后半周期地屈孕酮联合诊刮术治疗的效果非常显著,不仅可以有效改善患者术后子宫内膜厚度,还可降低不规则出血率,预防子宫内膜病变风险,提高生活质量,值得临床推广与应用。Objective To analyze the effect of dydrogesterone on perimenopausal patients with abnormal uterine bleeding caused by ovulation disorder after curettage.Methods 69 perimenopausal patients with abnormal uterine bleeding due to ovulation obstruction were selected and divided into group A,group B and group C according to different follow-up treatment methods after curettage,with 23 cases in each group.Group A chose to expect treatment after curettage due to rejection of subsequent drug treatment,group B received whole-cycle treatment after curettage with dydrogesterone,and group C received half-cycle treatment with dydrogesterone after curettage.Endometrial thickness,postoperative irregular bleeding rate and quality of life of patients in the three groups were compared.Results Before treatment,there was no significant difference in endometrial thickness among 3 groups(P>0.05).After treatment,the endometrial thickness of group B and C was significantly thinner than that of group A,with statistically significant difference(P<0.05),while there was no statistically significant difference between group C and GROUP B(P>0.05).The irregular bleeding rate of group B and GROUP C was 34.8%and 8.7%,respectively,which were significantly lower than 82.6%of group A(P<0.05).The irregular bleeding rate of group C was lower than group B,the difference was statistically significant(P<0.05).The physical function,physiological function and overall health score of patients in group B and C were significantly higher than those in group A,with statistical significance(P<0.05).There were no significant differences in body function,physiological function and overall health score between group B and group C(P>0.05).Conclusion for perimenopausal ovulation obstructive patients with abnormal uterine bleeding,clinical give half cycle after flexor progesterone combined clinical treatment effect is significant,not only can improve the postoperative patients with endometrial thickness,also can reduce irregular bleeding rate,the risk prevention of en

关 键 词：围绝经期排卵障碍性异常子宫出血 地屈孕酮 诊刮术 子宫内膜厚度 

分 类 号：R711.52[医药卫生—妇产科学]