左甲状腺素片(L-T4)对促排卵治疗中卵泡黄素化PCOS不孕患者正常排卵的意义研究  

Study on the Significance of Levothyroxine Tablets(L-T4)on Normal Ovulation in Infertile Patients with Follicle Luteinized PCOS in Ovulation Stimulation Therapy

作　　者：周运花 李芬芳 黄维瑜 ZHOU Yunhua;LI Fenfang;HUANG Weiyu(Department of Obstetrics and Gynecology,Maternal and Child Health Family Planning Service Center,Meizhou,Guangdong Province,514021 China)

机构地区：[1]梅州市妇幼保健计划生育服务中心妇产科,广东梅州514021

出　　处：《中外医疗》2021年第23期1-4,共4页China & Foreign Medical Treatment

基　　金：梅州市科技计划项目(2017B076)。

摘　　要：目的研究左甲状腺素片(L-T4)对促排卵治疗中卵泡黄素化多囊卵巢综合征(PCOS)不孕患者正常排卵的意义。方法方便选取该院2017年10月—2019年10月行诱导排卵的多囊卵巢综合征不孕患者120例,卵泡出现黄素化的患者设置为黄素化组(n=60),给予左甲状腺素片治疗:卵泡直径至18-24 mm并正常排出者设置对照组(n=60),不给于左甲状腺素片治疗。观察两组血清FT3、FT4、TSH水平情况,超声监测卵泡黄素化组左甲状腺素片治疗前后排出率。结果治疗前黄素化组血清FT3、FT4水平为(2.05±0.16)、(104.35±0.20)pmol/L,显著低于对照组(2.65±0.15)、(124.40±0.30)pmol/L,差异有统计学意义(t=21.191、430.743,P<0.05);TSH水平为(3.45±0.85)mIUmol/L,显著高于对照组(1.38±0.15)mIUmol/L,差异有统计学意义(t=18.577,P<0.05)。卵泡黄素化组治疗后FT3、FT4水平较治疗前显著提高,为(2.85±0.24)、(129.02±0.35)pmol/L,TSH水平较治疗前显著降低,为(2.63±1.10)mIUmol/L,差异有统计学意义(t=21.483、474.043、4.569,P<0.05)。治疗前卵泡黄素化组排出率为0.00%,治疗后卵泡黄素化组排出率为73.33%,治疗后卵泡黄素化组排出率较治疗前显著提高,差异有统计学意义(χ^(2)=69.474,P<0.05)。结论甲状腺激素变化与患者排卵异常相关,左甲状腺素片能够提高促排卵治疗中卵泡黄素化PCOS不孕患者排卵功能。Objective To study the significance of levothyroxine tablets(L-T4)on normal ovulation in luteinized polycystic ovary syndrome(PCOS)infertility patients in ovulation stimulation therapy.Methods Convenience selection 120 infertile patients with polycystic ovary syndrome during ovulation induction and ultrasound monitoring in the hospital from October 2017 to October 2019.The patients with luteinized follicles were selected as the luteinized group(n=60).Levothyroxine tablets were given treatment,and the follicles with a diameter of 18-24 mm and normal discharge were set up as a control group(n=60),and levothyroxine tablets were not given.The serum FT3,FT4,and TSH levels of the two groups were observed,and the discharge rate of levothyroxine tablets in the follicular luteinization group was monitored by ultrasound before and after treatment.Results Before treatment,the serum FT3 and FT4 levels in the luteinized group were(2.05±0.16)pmol/L and(104.35±0.20)pmol/L,which was significantly lower than those in the control group(2.65±0.15)pmol/L,(124.40±0.30)pmol/L,the difference was statistically significant(t=21.191,430.743,P<0.05);TSH level was(3.45±0.85)mIU/mL,significantly higher than the control group(1.38±0.15)mIU/mL,the difference was statistically significant(t=18.577,P<0.05).After treatment,the levels of FT3 and FT4 in the luteinized follicle group were significantly higher than those before treatment,which were(2.85±0.24)pmol/L,(129.02±0.35)pmol/L,and TSH levels were significantly lower than before treatment,which was(2.63±1.10)mID/mL,the difference was statistically significant(t=21.483,474.043,4.569,P<0.05).The discharge rate of the follicle luteinization group before treatment was 0.00%,and the discharge rate of the follicle luteinization group was 73.33%after treatment.After treatment,the discharge rate of the follicle luteinization group was significantly higher than before treatment,the difference was statistically significant(χ^(2)=69.474,P<0.05).Conclusion The change of thyroid hormone is relate

关 键 词：左甲状腺素片 促排卵治疗 卵泡黄素化 多囊卵巢综合征 不孕 排卵功能 甲状腺激素 

分 类 号：R4[医药卫生—临床医学]