TIMP2和IGFBP7的生物学功能及其在肾脏损伤过程中作用的研究进展  

Research progress on the biological functions of TIMP2 and IGFBP7 and their roles in acute kidney injury

作　　者：张杨(综述) 王一梅 姜物华 赵栓 丁小强(审校) ZHANG Yang;WANG Yi-mei;JIANG Wu-hua;ZHAO Shuan;DING Xiao-qiang(Department of Nephrology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Kidney and Dialysis Institute of Shanghai,Shanghai 200032,China;Kidney and Blood Purification Laboratory of Shanghai,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院肾内科,上海200032 [2]上海市肾病与透析研究所,上海200032 [3]上海市肾脏疾病与血液净化重点实验室,上海200032

出　　处：《复旦学报（医学版）》2021年第5期671-679,共9页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(81800596);上海市“重中之重”临床医学中心和临床重点学科建设计划(2017ZZ01015)。

摘　　要：急性肾损伤(acute kidney injury,AKI)是临床常见危重症,发生率高,死亡率高。AKI的早期诊断和治疗是降低死亡率和治疗成本的有效方法。目前临床上早期诊断AKI的生物标志物是尿液中金属蛋白酶组织抑制因子2(tissue inhibitors of metalloproteinase 2,TIMP2)和胰岛素样生长因子结合蛋白7(insulin-like growth factor binding protein 7,IGFBP7)浓度的乘积。TIMP2和IGFBP7的生物学功能,特别是在肾脏中的作用尚不清楚。本文首先分析二者所属家族的蛋白特征和生物学功能,再对二者在肾脏发育和AKI过程中的作用进行文献分析,从而为临床医师深入了解TIMP2和IGFBP7作为AKI生物标志物之外的作用和功能提供参考,并为其准确利用TIMP2和IGFBP7诊断和治疗AKI提供依据。Acute kidney injury(AKI)is a common clinical critical complication with high incidence and mortality.Early diagnosis and treatment of AKI is an effective way to reduce mortality and treatment costs.At present,the biomarker for diagnosis of AKI is the product of the concentration of tissue inhibitors of metalloproteinase 2(TIMP2)and insulin-like growth factor binding protein 7(IGFBP7)in urine.However,the biological functions of TIMP2 and IGFBP7,especially in the kidney,remain unclear compared with other biomarkers of AKI.Therefore,we reviewed the protein characteristics and biological functions of the two families,as well as the role of the two proteins in kidney development and AKI progression,which can provide a theoretical reference for clinicians to understand TIMP2 and IGFBP7 in addition to their role as AKI biomarkers and a new perspective for more accurate and efficient use of TIMP2 and IGFBP7 in diagnosis and treatment of AKI.

关 键 词：急性肾损伤(AKI) 生物标志物 金属蛋白酶组织抑制因子2(TIMP2) 胰岛素样生长因子结合蛋白7(IGFBP7) 

分 类 号：R692[医药卫生—泌尿科学]