阿奇霉素联合中医内服外治法对小儿支原体肺炎的疗效及安全性观察  

Clinical Effects and Safety of Azithromycin Plus Oral and External TCM Therapy in Mycoplasma Pneumonia Children

作　　者：肖宗浩 洪标华 XIAO Zong-hao;HONG Biao-hua(Pediatric Department,Meizhou City Maternaity and Child Health Family Planning Service Center,Meizhou,Guangdong 514000)

机构地区：[1]广东省梅州市妇幼保健计划生育服务中心儿科,广东梅州514000

出　　处：《智慧健康》2021年第17期182-184,共3页Smart Healthcare

摘　　要：目的分析阿奇霉素加中医内服外治法对支原体肺炎(Mycoplasma Pneumonia,MPP)患儿的疗效。方法将2020年1月至2020年12月本院收治的MPP患儿总共78例为研究对象,将78例患儿从1随机编号至78,后将编号为奇数的39例患儿纳入对照组(予以阿奇霉素),编号为偶数的39例患儿纳入观察组(于对照组前提下加以清金化痰汤及穴位敷贴),统计并比较两组治疗后的有效率、喘息、肺啰音、咳嗽和发热等症状消失时间、白细胞计数(WBC)、中性粒细胞比例(NEU)、C-反应蛋白(CRP)水平与不良反应情况。结果观察组有效率高于对照组(P<0.05)。观察组的喘息、肺啰音、咳嗽和发热消失时间均短于对照组(P<0.05)。治疗后,两组WBC、NEU及CRP水平均降低,且观察组WBC、NEU及CRP水平低于对照组(P<0.05)。两组不良反应情况无显著差异(P>0.05)。结论阿奇霉素加中医内服外治法对MPP疗效确切,能改善其临床症状,减轻其机体的炎症反应,同时用药后不良反应无显著增加,安全性较高,值得采用。Objective To analyze the effects of Azithromycin plus oral and external TCM therapy in mycoplasma pneumonia(MPP) children. Methods 78 MPP children treated from January 2020 to December 2020 in our hospital were chosen as research subjects. Children were randomly coded from number 1 to number 78. 39 children(odd number) were included in the control group(Azithromycin);39 children(even number) were included in the observation group(Azithromycin plus Qingjin Huatan decoction and acupoint application). Effective treatment rate, disappearance time of clinical symptoms like wheezing, lung rale, cough and fever, white blood cell count(WBC), neutrophile granulocyte percentage(NEU), C-reactive protein(CRP) and adverse reactions were counted. Results The effective treatment rate in the observation group was higher than that in the control group(P<0.05);the disappearance time of wheezing, lung rale, cough and fever in the observation group was shorter than that of the control group(P<0.05);WBC, NEU and CRP levels for two groups were reduced, but related values in the observation group were even lower than those of the control group(P<0.05);there were no significant between-group differences about the adverse event rate(P>0.05). Conclusion Azithromycin combined with oral and external TCM therapy can reduce the clinical symptoms and inflammatory response, produce less effect on the adverse reactions and increase the treatment safety for MPP children.

关 键 词：支原体肺炎 穴位贴敷 阿奇霉素 清金化痰汤 症状消失时间 不良反应 

分 类 号：R725.6[医药卫生—儿科]