霍山石斛化学成分研究  

Chemical constituents of Dendrobium huoshanense C.Z.Tang et S.J.Cheng

作　　者：赵宏苏[1,2] 许凤清 陈箫箫[1] 胡江苗 曾凡俊 彭代银[1] 吴德玲 ZHAO Hong-su;XU Feng-qing;CHEN Xiao-xiao;HU Jiang-miao;ZENG Fan-jun;PENG Dai-yin;WU De-ling(Anhui Province Key Laboratory of Research&Development of Chinese Medicine,Anhui University of Chinese Medicine;Anhui Provincial Key Laboratory of New Manufacturing Technology for Traditional Chinese Medicine Decoction Pieces,Hefei 230012,China;Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;General Administration of Customs(Beijing)International Travel Health Care Center,Beijing 100013,China)

机构地区：[1]安徽中医药大学中药研究与开发安徽省重点实验室 [2]中药饮片制造新技术安徽省重点实验室,合肥230012 [3]中国科学院昆明植物研究所,昆明650201 [4]海关总署(北京)国际旅行卫生保健中心,北京100013

出　　处：《天然产物研究与开发》2021年第9期1491-1498,共8页Natural Product Research and Development

基　　金：国家自然科学基金(U19A2009);安徽中医药大学自然科学基金重点项目(2020zrzd14)。

摘　　要：研究霍山石斛Dendrobium huoshanense Tang et Cheng茎的化学成分。应用硅胶、Sephadex LH-20、MCI-gel、Rp-18结合Semi-prep HPLC技术进行分离纯化,从霍山石斛茎中分离得到29个化合物,分别鉴定为4,4′-二羟基-3,5-二甲氧基联苄(1)、batatasin Ⅲ(2)、5,4′-二羟基-3-甲氧基联苄(3)、二氢松柏醇二氢对羟基桂皮酸酯(4)、对羟基苯丙酸甲酯(5)、二氢松柏醇(6)、二氢阿魏酸(7)、松柏醛-4-O-β-D-吡喃葡萄糖苷(8)、4-烯丙基-2,6-二甲氧-苯基葡萄糖苷(9)、erythrosyringoylglycerol-4-O-β-D-glucopyranoside(10)、3,4,5-trihydroxyallylbenzene-3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranoside(11)、(7S,8R)syringylglycerol-8-O-4′-sinapyl ether 4-O-β-D-glucopyranoside(12)、3,4-二羟基-5-甲氧基苯甲醛(13)、对羟基苯甲酸(14)、5-hydroxylated isobenzofuran-1(3H)-one(15)、3,5-二甲氧基-4-羟基-苯甲醛(16)、4-羟基-3-甲氧基苯甲醛(17)、3,4,5-trimethoxyphenol-1-O-β-D-glucopyranoside(18)、天麻苷(19)、丁香脂素(20)、丁香脂素-4-O-β-D-葡萄糖苷(21)、丁香脂素-4,4′-O-β-D-二葡萄糖苷(22)、柚皮素(23)、2,6-二甲氧基对苯醌(24)、5-羟甲基糠醛(25)、tetrahydro-5-oxo-2-furancarboxylic acid methyl ester(26)、焦谷氨酸甲酯(27)、川芎哚(28)和尿嘧啶核苷(29)。其中化合物5~19、21~29位为首次从该植物中分离得到,化合物8、10、11、15、16、18、26、28为首次从石斛属中分离得到。To investigate the chemical constituents of Dendrobium huoshanense Tang et Cheng.29 compounds were isolated from this plant by multiple column chromatography, such as silica gel, Sephadex LH-20,MCI gel, Rp-18 and semi-preparation HPLC,their structures were elucidated by means of extensive spectroscopic analysis and identified as follows: 4,4′-dihydroxy-3,5-dimethoxybibenzyl(1),batatasin Ⅲ(2),5,4′-dihydroxy-3-methoxybibenzyl(3),dihydroconiferyl dihydrop-hydroxycinnamate(4),methyl 3-propionate(5),dihydroconiferyl alcohol(6),dihydroferulic acid(7),4-O-β-D-glucopyranosyl coniferyl aldehyde(8),4-allyl-2,6-dimethoxyphenyl glucopyranoside(9),erythrosyringoylglycerol-4-O-β-D-glucopyranoside(10),3,4,5-trihydroxyallylbenzene-3-O-β-D-glucopyranosyl-4-O-β-D-glucopyranoside(11),(7S,8R)-syringylglycerol-8-O-4′-sinapyl ether 4-O-β-D-glucopyranoside(12),3,4-dihydroxy-5-methoxybenzaldehyde(13),p-hydroxybenzoic acid(14),5-hydroxylated isobenzofuran-1(3 H)-one(15),3,5-dihydroxy-4-hydroxy benzaldehyde(16),4-hydroxy-3-methoxybenzaldehyde(17),3,4,5-trimethoxyphenol-1-O-β-D-glucopyranoside(18),gastrodin(19),(+)-syringaresinol(20),(+)-syringaresinol-4-O-β-D-glucopyranoside(21),liriodendrin(22),naringenin(23),2,6-dimethoxy-p-benzoquinone(24),5-hydroxymethyl furfural(25),tetrahydro-5-oxo-2-furancarboxylic acid methyl ester(26),methyl pyroglutamate(27),periloyrine(28) and uridine(29).Compounds 5-19,21-29 were isolated from this plant for the first time and 8,10,11,15,16,18,26,28 were isolated from this genus.

关 键 词：霍山石斛 化学成分 联苄 苯丙素 

分 类 号：Q939.97[生物学—微生物学]