尼可地尔联合前列地尔治疗顽固性心绞痛的临床效果及对患者血流动力学、氧化应激指标的影响  

Clinical effect of nicorandil combined with alprostadil in the treatment of refractory angina pectoris and its influences on hemodynamics and oxidative stress indexes

作　　者：杨丽 吴锦涛 肖启娥 YANG Li;WU Jintao;XIAO Qi'e(Chenggu Hospital of Traditional Chinese Medicine,Hanzhong 723200;the Second People's Hospital of Chenggu County,Hanzhong 723200,China)

机构地区：[1]城固县中医医院,陕西汉中723200 [2]城固县第二人民医院,陕西汉中723200

出　　处：《临床医学研究与实践》2021年第27期36-38,共3页Clinical Research and Practice

摘　　要：目的探讨尼可地尔联合前列地尔治疗顽固性心绞痛的临床效果及对患者血流动力学、氧化应激指标的影响。方法选取2018年6月至2020年6月我院收治的214例顽固性心绞痛患者作为研究对象,随机将其分为对照组和观察组,各107例。对照组给予前列地尔治疗,观察组给予尼可地尔联合前列地尔治疗。比较两组患者的临床疗效、心功能指标、血流动力学、氧化应激指标、不良反应发生情况。结果观察组的治疗总有效率为91.59%,高于对照组的82.24%(P<0.05)。治疗后,观察组的左室射血分数(LVEF)高于对照组,左室收缩末期内径(LVESD)、QT间期离散度(QTd)均小于对照组(P<0.05)。治疗后,观察组患者的心输出量(CO)、每搏输出量(SV)、心脏指数(CI)均高于对照组(P<0.05)。治疗后,观察组的同型半胱氨酸(Hcy)、脂蛋白a[LP(a)]、肌酸激酶同工酶(CK-MB)水平均低于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P=0.270)。结论尼可地尔联合前列地尔治疗顽固性心绞痛患者可获得良好的治疗效果,有助于改善患者的心功能、血流动力学指标,降低氧化应激水平,且安全性良好。Objective To investigate the clinical effect of nicorandil combined with alprostadil in the treatment of refractory angina pectoris and its influences on hemodynamics and oxidative stress indexes.Methods A total of 214 patients with refractory angina pectoris admitted in our hospital from June 2018 to June 2020 were selected as the research objects and randomly divided into control group and observation group,with 107 cases in each group.The control group was treated with alprostadil,and the observation group was treated with nicorandil combined with alprostadil.The clinical efficacy,cardiac function index,hemodynamics,oxidative stress index and adverse reactions were compared between the two groups.Results The total effective rate of treatment of the observation group was 91.59%,which was higher than 82.24%of the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the observation group was higher than that in the control group,and the left ventricular end systolic diameter(LVESD)and QT interval dispersion(QTd)were smaller than those in the control group(P<0.05).After treatment,the cardiac output(CO),stroke output(SV)and cardiac index(CI)of the observation group were higher than those of the control group(P<0.05).After treatment,the levels of homocysteine(Hcy),lipoprotein a[LP(a)]and creatine kinase isoenzyme(CK-MB)in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P=0.270).Conclusion Nicorandil combined with alprostadil in the treatment of patients with refractory angina pectoris can obtain good therapeutic effect,it help to improve patients'cardiac function and hemodynamics indexes,reduce the levels of oxidative stress,and have good safety.

关 键 词：顽固性心绞痛 尼可地尔 心功能 血流动力学 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病]