非对映异构体拆分法拆分消旋体2-四氢糠酸的研究进展  

Research Progress on Resolution of Racemic Tetrahydrofuran-2-formic Acid by Diastereomeric Resolution

作　　者：何佳钰 秦晋晶 皮中庆 李振华[1] HE Jia-yu;QIN Jin-jing;PI Zhong-qing;LI Zhen-hua(College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China)

机构地区：[1]浙江工业大学药学院,浙江杭州310014

出　　处：《浙江化工》2021年第9期15-20,共6页Zhejiang Chemical Industry

摘　　要：2-四氢糠酸的两种光学异构体均可作为手性构建模块,在医药领域中发挥巨大作用。非对映异构体拆分法通常被认为是最直接、最经济的手性分离方法,并广泛应用于工业生产中。本文综述了非对映异构体拆分法拆分2-四氢糠酸的研究进展。Both optical isomers of tetrahydrofuran-2-formic acid can be used as chiral building blocks and play an important role in the field of medicine.The diastereoisomer resolution is generally considered to be the most direct and economical method in chiral separation,and is widely used in industrial production.This paper reviews the research progress of the resolution of tetrahydrofuran-2-formic acid by diastereomeric resolution.

关 键 词：2-四氢糠酸 化学拆分 非对映异构体拆分 

分 类 号：TQ225[化学工程—有机化工]