注射用促肝细胞生长素致过敏性休克33例文献分析  

Literature analysis of 33 cases of anaphylactic shock induced by hepatocyte growth-promoting factor for injection

作　　者：阮广新 何淑妍[1] RUAN Guang-xin;HE Shu-yan(Department of Pharmacy,Jiangmen Central Hospital,Jiangmen 529030,China)

机构地区：[1]江门市中心医院药学部,广东江门529030

出　　处：《中国药物应用与监测》2021年第4期256-259,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨注射用促肝细胞生长素致过敏性休克的临床特点和影响因素,为临床安全用药提供参考。方法:检索CNKI、万方数据库,查阅1995–2019年国内报道的注射用促肝细胞生长素致过敏性休克病例报告并进行统计分析。结果:共检索到33例促肝细胞生长素致过敏性休克患者,年龄主要分布于41~60岁(54.55%),男性明显多于女性;速发型过敏性休克(发生在用药30 min内)占90.91%;累及系统/器官以心血管系统、呼吸系统、皮肤及其附件以及全身性损害多见;31例经抢救后治愈,2例病情加重。休克患者恢复时间与药物治疗方案无关,但与发生过敏性休克时血压的高低有关。结论:注射用促肝细胞生长素致过敏性休克发病迅速且剧烈,影响因素较多,建议临床严格遵循药品说明书用药并加强用药监护。Objective:To explore the clinical characteristics and influencing factors of anaphylactic shock induced by hepatocyte growth-promoting factor for injection(pHGF)in order to provide references for clinical safe drug use.Methods:The CNKI and WanFang databases were searched and the cases of anaphylactic shock caused by pHGF reported in China from 1995 to 2019 were statistically analyzed.Results:In 33 cases with anaphylactic shock induced by pHGF,most patients were within 41–60 years old(54.55%).Male patients were obviously more than female patients.Patients with immediate anaphylactic shock(happened within 30 min)were accounted for 90.91%.The systems/organs mainly involved in anaphylactic shock induced by pHGF were cardiovascular system,respiratory system,skin and its accessories and systemic damage.31 cases were cured after rescue,and 2 cases were aggravated.The recovery time of shock patients was not related to the drug treatment regimen,but related to the level of blood pressure in the event of anaphylactic shock.Conclusion:Anaphylactic shock induced by pHGF was rapid and fierce with many influencing factors.It should be used strictly in accordance with the package insert and drug monitoring should be strengthened.

关 键 词：促肝细胞生长素 过敏性休克 文献分析 药品不良反应 

分 类 号：R969.3[医药卫生—药理学] R975[医药卫生—药学]