《心力衰竭的通用定义和分类》解读  

Interpretation of Universal Definition and Classification of Heart Failure

作　　者：肖小菊 黎励文[1] XIAO Xiaoju;LI Liwen(Guangdong Provincial People's Hospital,Guangdong Cardiovascular Institute,Guangdong Provincial Key Laboratory of Coronary Heart Disease,Guangzhou,510000,P.R.China)

机构地区：[1]广东省人民医院广东省心血管病研究所广东省冠心病重点实验室,广州510000

出　　处：《中国胸心血管外科临床杂志》2021年第10期1140-1144,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：广东省冠心病重点实验室基金(2017B030314041)。

摘　　要：《心力衰竭的通用定义和分类》共识提出了心力衰竭的通用定义、分类和分期标准。心力衰竭患病率仍在持续上升,射血分数保留的心力衰竭(H FpEF)表型变得越来越普遍。神经-内分泌拮抗剂治疗射血分数降低的心力衰竭(HFrEF)患者疗效显著,但目前尚无有效的药物可改善HFpEF患者的临床预后。HFpEF的病理生理机制涉及代谢-炎症机制紊乱、心外膜脂肪组织堆积、冠状动脉微血管功能障碍,需要进一步的研究证实针对这些机制的探索性治疗是否对HFpEF患者获益。另外,HFrEF患者经治疗射血分数改善和心功能恢复后也不能中断心力衰竭药物治疗。The Universal Definition and Classification of Heart Failure consensus has proposed the universal definition,classification and staging criteria of heart failure.The prevalence of heart failure is still increasing,and the phenotype of heart failure with preserved ejection fraction(HFpEF)is becoming more and more common.Neuroendocrine antagonists are effective in treating patients with heart failure with reduced ejection fraction(HFrEF).However,there is no effective drug that can improve the clinical prognosis of patients with HFpEF.The pathophysiological mechanism of HFpEF involves metabolic-inflammatory mechanism disorders,epicardial fat tissue accumulation,and coronary microvascular dysfunction.The exploratory treatment of these mechanisms requires further research to confirm whether it is beneficial to patients with HFpEF.In addition,the improvement of ejection fraction and the recovery of cardiac function in patients with HFrEF after treatment cannot interrupt the drug treatment of heart failure.

关 键 词：心力衰竭 左心室射血分数 利钠肽 指南解读 

分 类 号：R541.6[医药卫生—心血管疾病]