前列腺素E2诊断膀胱过度活动症的Meta分析  

Prostaglandin E2 in the diagnosis of overactive bladder:a Meta-analysis

作　　者：熊志 任杰[1] 郝晓杰 高宏飞[2] Xiong Zhi;Ren Jie;Hao Xiaojie;Gao Hongfei(Shanxi Medical University,Shanxi 030001,China;Department of Urology,the First Hospital of Shanxi Medical University,Shanxi 030001,China)

机构地区：[1]山西医科大学,太原030001 [2]山西医科大学第一医院泌尿外科,太原030001

出　　处：《国际泌尿系统杂志》2021年第5期780-784,共5页International Journal of Urology and Nephrology

基　　金：山西省留学回国人员科技活动择优资助项目(晋人社厅函[2017]397号)。

摘　　要：目的探讨前列腺素E2(PGE2)与膀胱过度活动症(OAB)的关系。方法通过计算机从PubMed、Web of Science、Embase、Cochrane Library、知网和万方数据库中检索建库至2020年4月所有关于PGE2与OAB关系的临床随机对照试验文献资料,由2名研究者独立进行文献筛选、数据提取及文献质量评价,使用Review Manager Version 5.3软件进行Meta分析。结果共纳人6篇文献。分析结果显示,OAB组患者的尿PGE2水平均明显高于对照组(SMD=3.85,95%CI:0.96~6.74,P=0.009);OAB患者的尿PGE2/Cr水平高于间质性膀胱炎/膀胱疼痛综合征(IC/PBS)患者,差异有统计学意义(SMD=0.39,95%CI:0.04〜0.74,P=0.03)。结论OAB患者尿PGE2水平明显增高,但尿PGE2尚不能作为诊断OAB的潜在生物标志物,也不能作为鉴别0AB和IC/PBS的潜在生物标志物。Objective To investigate association between urinary prostaglandin E2(PGE2)and overactive bladder(OAB).A Meta-analysis was formulated to appraise the diagnostic role of urinary PGE2 in OAB.Methods Studies about the relationship between urinary PGE2 and OAB were i-dentified by searching PubMed,Web of Science,Embase,Cochrane library CNKI and WanFang date-base from inception to April 2020 by computer.Literature screening,data extraction and literature quality evaluation were performed by two researchers independently,and Meta-analysis was performed using Review Manager Version 5.3 software.Results A total of 6 published studies were included in this Meta-analysis.The results showed that the level of urinary PGE2(SMD=3.85,95%CI:0.96〜6.74,P=0.009)in patients with OAB was significantly higher than control group.There was a signif-icant difference in the level of urinary PGE2/Cr(SMD=0.39,95%C7:0.04〜0.74,P=0.03)be-tween patients with OAB and those with interstitial cystitis/painful bladder syndrome(IC/PBS).Conclusions This Meta-analysis shows that it is believable that the level of urinary PGE2 is significantly increased in patients with OAB,hut urinary PGE2 does not seem to be a potential biomarker for the diagnosis of OAB,nor can it be used as a potential biomarker for the identification of OAB and IC/PBS.Due to the limitations of the sample size and quality of the study,whether urinary PGE2 can be used as a biomarker of OAB in clinical application,more high-quality studies should be carried out to strictly control the confounding factors.

关 键 词：膀胱 过度活动性 前列腺素E类 尿肌酐 

分 类 号：R694[医药卫生—泌尿科学]