钯催化串联Heck环化反应制备氮杂桥环化合物  

Palladium-Catalyzed Tandem Heck Cyclization Reactions to Access the Bridged N-Heterocyclic Compounds

作　　者：李曼 汪颖 徐允河 Li Man;Wang Ying;Xu Yunhe(Department of Chemistry,University of Science and Technology of China,Hefei 230026)

机构地区：[1]中国科学技术大学化学与材料科学学院,合肥230026

出　　处：《有机化学》2021年第8期3073-3082,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21871240);中央高校基本科研业务费专项资金(No.WK2060000017)资助项目.

摘　　要：报道了一种钯催化分子内Heck环化串联反应.该反应使用3-取代保护的吲哚酰胺衍生物作为原料,碘化钯作为催化剂,4-(二甲氨基)三苯基膦作为配体,在乙腈和甲苯混合溶剂中发生串联反应,以优良的收率合成了氮杂桥环化合物.该反应具有良好的官能团兼容性和较高的合成效率,为“一锅法”构建稠环化合物提供了一种简便的方法.Palladium-catalyzed intramolecular Heck tandem cyclization reactions were developed. With palladium iodide as a catalyst and 4-(dimethylamino)triphenylphosphine as a ligand, 3-substituted indoleamide derivatives were converted to bridged N-heterocyclic products in good yields under simple reaction conditions. The tandem reactions are featured by efficient construction of fused ring compounds in one pot and good functional group compatibility.

关 键 词：钯催化剂 分子内Heck串联环化反应 氮杂桥环化合物 一锅法 

分 类 号：O626[理学—有机化学]